Β-SHEET

作品数：26被引量：33H指数：3
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相关领域：生物学更多>>
相关作者：王婷邵正中李萌萌岳媛媛徐晓帆更多>>
相关机构：复旦大学教育部重庆医科大学复旦大学上海医学院更多>>
相关期刊：《Bioactive Materials》《Journal of Analytical Sciences, Methods and Instrumentation》《Transactions of Tianjin University》《Open Journal of Biophysics》更多>>
相关基金：国家自然科学基金重庆市自然科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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Arginine-solubilized lipoic acid-induced β-sheets of silkfibroin-strengthened hydrogel for postoperative rehabilitation ofbreast cancer
《Bioactive Materials》2024年第10期667-682,共16页Zhuodan Zhang Yi Xia Xinyi Li Qian Zhang Yuanhao Wu Chunyan Cui Jianfeng Liu Wenguang Liu 
support for this work from the National Natural Science Foundation of China(Grant No.52233008,52303201,32301120);Program for talents in Scientific and technological Innovation of Tianjin University(Grant No.2023XQM-0047);the CAMS Innovation Fund for Medical Sciences(2023-12M-QJ-016,2022-I2M-2-003,2021-I2M-1060).
Breast cancer is the most common cancer among women worldwide, and adjuvant radiotherapy (RT) followingtumor removal is one of the most commonly used treatments for breast cancer. However, the high risk of tumorrecurr...
关键词：α-lipoic acid Adhesive hydrogel Injectable hydrogel Tumor inhibition Wound healing 
Ionic liquids inhibit the dynamic transition fromα-helices toβ-sheets in peptides被引量：1
《Fundamental Research》2024年第4期777-784,共8页Ju Liu Yanlei Wang Feng Huo Hongyan He 
the National Natural Science Foundation of China(21834006,22078322,21978293,and 21978027);the Youth Innovation Promotion Association of CAS(2021046,Y2021046);State Key Laboratory of Treatments and Recycling for Organic Effluents by Adsorption in Petroleum and Chemical Industry(SDHY2114).
Abnormalities in the transition betweenα-helices andβ-sheets(α-βtransition)may lead to devastating neurodegenerative diseases,such as Parkinson's syndrome and Alzheimer's disease.Ionic liquids(ILs)are potential dr...
关键词：α-βtransition Moleculardynamics simulation lonic liquids Machine learning Membrane channel protein 
3D printedβ-sheet-reinforced natural polymer hydrogel bilayer tissue engineering scaffold被引量：3
《Science China(Technological Sciences)》2024年第4期1170-1184,共15页ZHAO XinRui NIE XiongFeng ZHANG XiaoPing SUN YaGe YANG Rong BIAN XinYu ZHANG Qian WANG HongYing XU ZiYang LIU WenGuang 
supported by the National Key Research and Development Program of China(Grant No.2018YFA0703100)。
It remains a significant challenge to fabricate natural polymer(NP)hydrogels with anti-swelling ability and high strengths in the physiological environment.Herein,theβ-sheet-reinforced NP hydrogel is developed by cop...
关键词：silk fibroin Β-SHEET high-strength hydrogel natural polymer osteochondral regeneration 
Methyl-CpG binding domain(MBD)2/3 specifically recognizes and binds to the genomic mCpG site with a β-sheet in the MBD to affect embryonic development in Bombyx mori被引量：1
《Insect Science》2023年第6期1607-1621,共15页Tong-Yu Fu Shuang-Shun Ji Yu-Lin Tian Yi-Guang Lin Yu-Mei Chen Qi-En Zhong Si-Chun Zheng Guan-Feng Xu 
funded by the National Natural Sci-ence Foundation of China,grant numbers 32100374 and 31872286.
Methyl-CpG(mCpG)binding domain(MBD)proteins especially bind with methylated DNA,and are involved in many important biological processes;however,the binding mechanism between insect MBD2/3 and mCpG remains unclear.In t...
关键词：embryonic development insects MBD2/3 methyl-CpG binding domain(MBD) Β-SHEET 
Distorted aryl homochirality controlled byβ-sheet folding
《Chinese Chemical Letters》2023年第11期147-152,共6页Yunying Xu Aiyou Hao Pengyao Xing 
supported by the National Natural Science Foundation of China(Nos.21901145,22171165);the financial support from Youth cross-scientific innovation group of Shandong University(No.2020QNQT003).
Distortion of planar aromatics occurs in the fused rings conjugated with bulky substituents,which generates racemic enantiomers with high transformation energy barriers.However,direct synthesis of homochiral distorted...
关键词：Distorted chirality FOLDING Solvent strategy Chiroptical activity 
Highly Ordered Supramolecular Assembled Networks Tailored by Bioinspired H-Bonding Confinement for Recyclable Ion-Transport Materials被引量：5
《CCS Chemistry》2023年第6期1422-1432,共11页Chen-Yu Shi Qi Zhang Bang-Sen Wang Dan-Dan He He Tian Da-Hui Qu 
This work was supported by the National Natural Science Foundation of China(grant nos.22025503,21790361,21788102,and 21871084);Shanghai Municipal Science and Technology Major Project(grant no.2018SHZDZX03);the Fundamental Research Funds for the Central Universities,the Programme of Introducing Talents of Discipline to Universities(grant no.B16017);Program of Shanghai Academic/Technology Research Leader(grant no.19XD1421100),Science and Technology Commission of Shanghai Municipality(grant no.21JC1401700);the Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study(grant no.SN-ZJU-SIAS-006).The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for help on the material characterization.
Controlling dynamic molecular self-assembly to finely tune macroscopic properties offers chemical solutions to rational material design.Here we report that combining disulfide-mediated ring-opening polymerization with...
关键词：dynamic chemistry poly(disulfide)s β-sheet-like H-bonds ion conductivity chemical recyclability 
An atomistic model of silk protein network for studying the effect of pre-stretching on the mechanical performances of silks被引量：1
《Acta Mechanica Sinica》2022年第6期55-68,I0001,共15页Wenhui Shen Zihan Tang Xuwei Wu Liang Pan Yuan Cheng Bo Huo Jizhou Song Weiqiu Chen Baohua Ji Dechang Li 
This work was supported by the National Natural Science Foundation of China(Grants Nos.12122212,11932017,11772054,and 11772055).
Silk protein builds one of the strongest natural fibers based on its complex nanocomposite structures.However,the mechanical performance of silk protein,related to its molecular structure and packing is still elusive....
关键词：Silk protein Amorphous domain β-sheet crystallite Mechanical performances Molecular dynamics 
Promoting effect of a calcium-responsive self-assemblyβ-sheet peptide on collagen intrafibrillar mineralization
《Regenerative Biomaterials》2022年第1期761-774,共14页Zhongcheng Li Qian Ren Sili Han Longjiang Ding Xi Qin Die Hu Ting He Tian Tian Ziqian Lu Linglin Zhang 
supported by the National Natural Science Foundation of China(Grant Nos.81470734,Grant Nos.81970931).
Recently,a de novo synthetic calcium-responsive self-assemblyβ-sheet peptide ID8(Ile-Asp-Ile-Asp-Ile-Asp-Ile-Asp)has been developed to serve as the template inducing hydroxyapatite nucleation.The aim of this study wa...
关键词：COLLAGEN polyacrylic acid BIOMINERALIZATION biomimetic materials amorphous calcium phosphate 
A β-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease被引量：1
《Science China Chemistry》2020年第1期73-82,共10页Xiang Ma Yanqing Wang Jiai Hua Congyu Xu Tao Yang Jian Yuan Guiquan Chen Zijian Guo Xiaoyong Wang 
supported by the National Natural Science Foundation of China(21877059,31570809,21731004);the National Basic Research Program of China(2015CB856300);the Natural Science Foundation of Jiangsu Province(BK20150054);the Research Foundation of the Chinese State Key Laboratory of Coordination Chemistry(SKLCC1912)
Amyloid-βpeptide(Aβ)aggregates,particularly Aβoligomers,are established biomarker and toxic species in Alzheimer’s disease(AD).Early detection and disaggregation of Aβaggregates are of great importance for the tr...
关键词：Alzheimer’s disease theranostic agent amyloid-βpeptide fluorescent probe blood screening 
Supramolecular protein glue to boost enzyme activity被引量：2
《Science China Materials》2019年第9期1341-1349,共9页Yuna Shang Yue Liao Zhongju Ye Zhongyan Wang Lehui Xiao Jie Gao Qigang Wang Zhimou Yang 
supported by the National Science Fund for Distinguished Young Scholars(31825012);the National Key Research and Development Program of China(2017YFC1103502);the National Natural Science Foundation of China(NSFC,51773097,51873156 and 21876116);Tianjin Science Fund for Distinguished Young Scholars(17JCJQJC44900);the National Program for Support of Topnotch Young Professionals;the Fundamental Research Funds for the Central Universities;the Young Elite Scientists Sponsorship Program by Tianjin(TJSQNTJ-2017-16)
Proteins possess many biological functions.However, they can easily degrade or aggregate, thus losing their bioactivity. Therefore, it is very important to develop materials capable of interacting with proteins and fo...
关键词：protein glue coassemble Β-SHEET enzyme activity 
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