Arginine-solubilized lipoic acid-induced β-sheets of silkfibroin-strengthened hydrogel for postoperative rehabilitation ofbreast cancer  

作　　者：Zhuodan Zhang Yi Xia Xinyi Li Qian Zhang Yuanhao Wu Chunyan Cui Jianfeng Liu Wenguang Liu 

机构地区：[1]School of Material Science and Engineering,Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University,Tianjin,300352,China [2]State Key Laboratory of Advanced Medical Materials and Devices,Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Key Laboratory of Radiopharmacokinetics for Innovative Drugs,Tianjin Institutes of Health Science,Institute of Radiation Medicine,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin,300192,China [3]State Key Laboratory of Molecular Engineering of Polymers(Fudan University),China

出　　处：《Bioactive Materials》2024年第10期667-682,共16页生物活性材料（英文）

基　　金：support for this work from the National Natural Science Foundation of China(Grant No.52233008,52303201,32301120);Program for talents in Scientific and technological Innovation of Tianjin University(Grant No.2023XQM-0047);the CAMS Innovation Fund for Medical Sciences(2023-12M-QJ-016,2022-I2M-2-003,2021-I2M-1060).

摘　　要：Breast cancer is the most common cancer among women worldwide, and adjuvant radiotherapy (RT) followingtumor removal is one of the most commonly used treatments for breast cancer. However, the high risk of tumorrecurrence and inevitable radiation skin injury after RT remain fatal problems, seriously challenging the patient’spostoperative rehabilitation. Herein, a multifunctional poly (lipoic acid)-based hydrogel is constructed throughone-step heating the mixture of α-lipoic acid (LA)/arginine (Arg)/silk fibroin (SF), without introducing any nonnaturalmolecules. The multiple synergistic interactions among LA, Arg, and SF not only enhance the solubilizationof LA in aqueous systems but also stabilize poly(lipoic acid) through strong salt bridge hydrogen bondsand ionic hydrogen bonds. Intriguingly, the LA-based surfactant induced β-sheet transformation of SF can furthermodulate the bulk strength of the hydrogel. Regulating the content of LA in hydrogels not only allows efficientcontrol of hydrogel bioactivity but also enables the evolution of hydrogels from injectable forms to adhesivepatches. Based on the different biological activities and forms of hydrogels, they can be implanted internally orapplied externally on the mice’s skin, achieving simultaneous prevention of tumor recurrence post-surgery andassistance in treating radiation-induced skin damage after radiotherapy.

关 键 词：α-lipoic acid Adhesive hydrogel Injectable hydrogel Tumor inhibition Wound healing 

分 类 号：R737.9[医药卫生—肿瘤] TQ427.26[医药卫生—临床医学]