Multi-length scale bioprinting towards simulating microenvironmental cues  

作　　者：Elisabeth L Gill Xia Li Mark A. Birch Yan Yan Shery Huang 

机构地区：[1]Department of Engineering, University of Cambridge,Trumpington Street, Cambridge CB2 1PZ, UK [2]Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Cambridge, UK

出　　处：《Bio-Design and Manufacturing》2018年第2期77-88,共12页生物设计与制造（英文）

摘　　要：It is envisaged that the creation of cellular environments at multiple length scales, that recapitulate in vivo bioactive and structural roles, may hold the key to creating functional, complex tissues in the laboratory. This review considers recent advances in biofabrication and bioprinting techniques across different length scales. Particular focus is placed on 3D printing of hydrogels and fabrication of biomaterial fibres that could extend the feature resolution and material functionality of soft tissue constructs. The outlook from this review discusses how one might create and simulate microenvironmental cues in vitro. A fabrication platform that integrates the competencies of different biofabrication technologies is proposed. Such a multi-process, multiscale fabrication strategy may ultimately translate engineering capability into an accessible life sciences toolkit, fulfilling its potential to deliver in vitro disease models and engineered tissue implants.

关 键 词：3D bioprinting ELECTROSPINNING Additive manufacturing MICROENVIRONMENT Disease modelling TISSUEENGINEERING 

分 类 号：S482.39[农业科学—农药学] Q81[农业科学—植物保护]