神经炎症对阿尔茨海默病中tau蛋白的影响  

The effect of neuroinflammation on tau pathology in Alzheimer's disease

作　　者：张海波 林爱花 宫平 张岩 叶德全[1] 于洋[1] ZHANG Hai-bo;LIN Ai-hua;GONG Ping;ZHANG Yan;YE De-quan;YU Yang(Department of Pharmacology,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《中国新药杂志》2018年第19期2245-2252,共8页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(81571027;31270941)

摘　　要：阿尔茨海默病(Alzheimer's disease,AD)是一种多病因的中枢神经系统退行性疾病。以tau蛋白为主要组成成分的神经纤维缠结(neurofibrillary tangles,NFTs)是AD的一个重要病理特征。此外,越来越多的证据表明,神经系统炎症反应参与AD的整个病理进程。神经炎症对AD中tau蛋白的病理改变发挥着重要作用。一方面,神经炎症反应可以通过作用tau蛋白转录和转录后修饰,影响tau蛋白的异常聚集;另一方面,通过脑内的免疫细胞(神经胶质细胞)直接或间接影响寡聚tau蛋白的传播(tau seeding)。本文总结了近年来中枢神经系统炎症反应对tau蛋白病理改变的研究成果,为AD的研究提供新的思路,也为其治疗提供了新的潜在靶点。Alzheimer＇s disease（ AD） is a progressive neurodegenerative disease of the central nervous system. The aggregation of hyperphosphorylated tau protein into neurofibrillary tangles（ NFTs） is a hallmark brain lesion of AD. More and more evidence shows that the inflammatory response of the nervous system is involved in the entire pathological process of AD. Neuroinflammation plays an important role on tau pathology in AD. On one hand,neuroinflammation affects the accumulation of tau protein via mediating the transcription and posttranscriptional modification of tau. On the other hand,neuroimmune cells,are involved in the spread of tau oligomers（ tau oligomeric seeds）. In this review,the recent research results of the role of neuroinflammatory response on the pathological changes of tau protein are summarized,and the potential therapeutic value of neuroinflammation in AD are discussed.

关 键 词：阿尔茨海默病 TAU蛋白 神经炎症 神经免疫细胞 炎症因子 

分 类 号：R749.16[医药卫生—神经病学与精神病学]