氟哌噻吨美利曲辛对局部进展期胃癌术后同步放化疗患者焦虑、抑郁及生活质量的影响  

Effect of Deanxit on Amxiety,Depression and Quality of Life in Patients with Locally Advanced Gastric Cancer Postoperative of Chemotherapy radiotherapy

作　　者：张海洋[1] 吕柯[1] 钱国武[1] ZHANG Haiyang;LV Ke;QIAN Guowu(Department of General Surgery,Nanyang Hospital Affiliated to Zhengzhou University,Nan yang 473000,China)

机构地区：[1]郑州大学附属南阳医院(河南省南阳市中心医院)普外科

出　　处：《中国健康心理学杂志》2018年第12期1774-1777,共4页China Journal of Health Psychology

摘　　要：目的：探讨氟哌噻吨美利曲辛对局部进展期胃癌术后同步放化疗患者焦虑、抑郁及生活质量的影响。方法：选取2015年5月-2016年8月于我院接受局部进展期胃癌根治手术且参与术后同步放化疗患者86例,将所选患者按照治疗方法不同分为对照组,观察组;两组患者均进行健康辅导,对照组术后同步放化疗,观察组在对照组基础上加用氟哌噻吨美利曲辛治疗,观察两组患者焦虑、抑郁以及生活质量影响,并记录药物不良反应。结果：（1）治疗前两组SAS、SDS评分无明显差异,治疗后观察组SAS、SDS评分较治疗前明显下降,且明显低于对照组（t=-3.654,-4.666,P〈0.001）;（2）观察组总有效率为93. 02%（40/43）明显高于对照组76. 74%（33/43）（χ~2=4. 440,P=0.035）;（3）治疗前两组生存质量感觉、自我健康状况感觉、心理领域、生理领域、环境领域以及社会领域各项评分无显著差异,治疗后观察组生存质量感觉、自我健康状况感觉、心理领域、生理领域、环境领域以及社会领域各项评分明显高于对照组（t=3.872,3.437,3.137,P〈0.01;t=5.499,P〈0.001;t=2.562,2.864,P〈0.01）;（4）对照组不良反应发生率为2.33%,观察组不良反应发生率6.98%,两组比较,差异无统计学意义。结论：氟哌噻吨美利曲辛对局部进展期胃癌术后同步放化疗所产生的焦虑抑郁情绪以及术后生活质量均有明显改善,且药物副作用少。Objective：To investigate the effect of deanxit on anxiety,depression and quality of life in patients with locally advanced gastric cancer postoperative concurrent chemoradio therapy. Methods：From May 2015 to August 2016 in our hospital,a total of 86 patients with locally advanced gastric cancer underwent radical resection were treated with concurrent chemoradiotherapy,according to the different treatment and treatment methods the selected patients were divided into the control group and the observation group;Two groups of patients were given health counseling,the control group received concurrent chemoradiotherapy,the observation group took Deanxit treatment on the treatment of the control group;Anxiety,depression and quality of life of the two groups were observed and the drug adverse reaction was recorded. Results：（1） There were no significant difference in SAS and SDS scores between the two groups before treatment（ P〈0.05）,after treatment,the scores of SAS and SDS in the observation group were significantly lower than those before treatment,and significantly lower than those in the control group（ t =-3.654,-4.666;P〈0.001）;（2）The total effective rate of the observation group was 93.02%（40/43）,which was significantly higher than that of the control group 76.74%（33/43）（χ~2= 4. 440,P〈0. 05）;（3） Before treatment,There were no siqnificant differences in quality of life and its dimensions between two groups（ P〈0.05）,（ t = 4.323,5.929,7.045,P〈0.001）,after treatment,the scores of quality of life in the observation group were significantly higher than those in the control group（ t = 3.872,3. 437,3. 137,5. 499,2. 562,2. 864;P〈0. 01）;（4） The incidence of adverse reactions was 2.33% in the control group and 6.98% in the observation group.The difference between the two groups was not statistically significant（ P〉0.05）.Conclusion：Deanxit is beneficial for anxiety,depression and quality of life after locally advanced gastric cancer postoperative chemor

关 键 词：氟哌噻吨美利曲辛 进展期胃癌 焦虑 抑郁 生活质量 

分 类 号：R749.92[医药卫生—神经病学与精神病学]