FGF1:一种治疗糖尿病的新型潜在药物  

FGF1:a Potential Drug for Diabetes Mellitus

作　　者：王晓庆 尹良鸿 钱永常[1,2] WANG Xiao-Qing;YIN Liang-Hong;QIAN Yong-Chang(Traditional Chinese Medicine,School of Forestry and Biotechnology,Zhejiang A＆F University,Hangzhou 311300,China;Department of Integrative Biosciences,College of Veterinary Medicine and Biomedical Sciences,Texas A＆M University,College Station,Texas 77843.USA)

机构地区：[1]浙江农林大学林业与生物技术学院中药学科,杭州311300 [2]美国德州农工大学兽医与生物医学科学学院综合生物科学系,美国德州大学城77843

出　　处：《中国生物化学与分子生物学报》2018年第10期1037-1044,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.31600070);浙江省林业厅省院合作林业科技项目(No.2015SY04);浙江农林大学科研发展基金人才启动项目(No.2015FR015)资助~~

摘　　要：糖尿病是一种常见的内分泌代谢性疾病。糖尿病及其并发症的治疗是现代医学仍未解决的难题。常见的药物治疗有诸多不良反应,如胰岛素长期使用产生的胰岛素耐受。近年研究发现,酸性成纤维细胞生长因子(fibroblast growth factor 1,FGF1或aFGF)及其衍生物能够使2型糖尿病小鼠的血糖快速恢复至正常水平,且具有胰岛素增敏效果,规避了胰岛素治疗产生的耐受性问题。因此,人们对FGF1及其衍生物在开发新型T2DM疗法方面给予诸多期待。该综述系统介绍了FGF1的结构与功能、降糖功效的机制及新发现,对FGF1的2种注射方式和FGF家族在降糖作用方面进行了比较,并对FGF1在治疗糖尿病方面的研究进程进行展望,为调节血糖、解决胰岛素耐受性问题提供一种新的思路和方法。Diabetes mellitus is a common endocrine and metabolic disease. A clinical cure of diabetes and its complications remains to be resolved in modern medicine. Conventional drug therapy has many side effects, for instance the generation of insulin resistance from long-term usage. In recent years, studies have found that acidic fibroblast growth factor （ FGF1 or aFGF） and its derivative can rapidly restore normal blood glucose levels in type 2 diabetic mice and have insulin sensitization effects. Therefore, FGF1 and its derivatives have better perspectives in clinical practice for type 2 diabetes mellitus. This review comprehensively summarizes the structure and function of FGF1, the mechanism of hypoglycemic effects and the advance in diabetes. Two injection methods of FGF1 and the hypoglycemic effect of FGF1 with other FGF family members are compared, respectively. We also cover the research progress of FGF1 in clinical practice of diabetes. These efforts are to provide an ahernative idea to control blood glucose levels and clinically cure insulin resistance.

关 键 词：糖尿病 酸性成纤维细胞生长因子(FGF1或aFGF) 降血糖 胰岛素敏感 胰岛素抵抗 

分 类 号：R977.15[医药卫生—药品]