乳腔镜辅助下行保乳手术治疗乳腺癌预防复发的效果及对患者免疫功能的影响  

Effect of Breast Conserving Surgery Assisted by Breast Endoscopy on Prevention of Breast Cancer Recurrence and its Effect on Patients' Immune Function

作　　者：吴瑛琦[1] 于光辉[1] 桃丽 WU Yingqi;YU Guanghui;TAO Li(Department of Breast Surgery,Chiteng Hospital,Chiteng Inner Mongolia 024000,China)

机构地区：[1]赤峰市医院乳腺外科,内蒙古赤峰024000

出　　处：《解放军预防医学杂志》2018年第10期1329-1332,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的分析乳腔镜辅助下行保乳手术治疗乳腺癌预防复发的效果及对患者免疫功能的影响。方法选取我院2014年1月-2016年7月收治的乳腺癌患者98例,根据手术方法不同分为对照组和观察组。对照组患者采用传统保乳手术,观察组患者采用乳腔镜辅助下行保乳手术,分析两组患者治疗后的临床效果。结果观察组患者术中出血量、引流量均少于对照组,住院时间短于对照组,但淋巴结清扫数目与对照组比较,差异无统计学意义(P>0.05)。术前,两组患者免疫功能指标、PGE2、PCT、TNF-α水平比较,差异均无统计学意义(P> 0.05)。术后3 d,观察组患者PGE2、PCT、TNF-α水平均低于对照组,免疫功能指标优于对照组,差异有统计学意义(P<0.05)。术前,两组患者血清肿瘤标志物、VEGF-A、VEGFR-1水平比较,差异均无统计学意义(P>0.05)。术后,观察组患者血清肿瘤标志物、VEGF-A、VEGFR-1水平与对照组比较,差异均无统计学意义(P>0.05)。两组患者复发率比较,差异无统计学意义(χ~2=1.043,P=0.307)。结论乳腔镜辅助下行保乳手术治疗乳腺癌手术创伤小,对机体应激因子、免疫功能影响较小,抑制血清肿瘤标志物、VEGF-A表达效果与传统保乳手术相当。Objective To analyze the effect of breast conserving surgery assisted by breast endoscopy on the prevention of recurrence of breast cancer and its influence on the immune function of patients. Methods Ninety-eight patients with breast cancer admitted to our hospital between January 2014 and July 2016 were divided into the control group and observation group according to surgical methods. The patients in the control group underwent the conventional breast conserving operations,while those in the observation group were treated with breast endoscopy-assisted breast conserving surgery. The clinical effects of the two groups were compared. Results The amount of bleeding in the observation group was smaller than that of the control group and the length of hospital stay was shorter,but the number of lymph nodes dissected was not significantly different（ P〈0.05）. There was no significant difference between the two groups in immune function indexes,PGE2,PCT or TNF-alpha levels before operation（ P〈0.05）. Three days after operation,the levels of PGE2,PCT and TNF-alpha in the observation group were lower than those in the control group,but the immune function indexes were better. The difference was statistically significant（ P〈0.05）. The difference in serum tumor markers,VEGF-A and VEGFR was statistically significant between the two groups before operation. The case was the same after operation. There was no significant difference in the recurrence rate between the two groups（ χ~2= 1.043,P = 0.307）.Conclusion Breast conserving surgery assisted by breast endoscopy results in less trauma and has little effect on the body＇s stress factors and immune function. This approach can inhibit the expression of serum tumor marker（ VEGF-A） almost as effectively as traditional breast conserving surgery.

关 键 词：乳腔镜 保乳手术 乳腺癌 免疫功能 

分 类 号：R737.9[医药卫生—肿瘤]