脑梗死患者红细胞体积分布宽度的变化及临床意义  

The Clinical Significance of Red Cell Distribution Width (RDW) in Patients with Cerebral Infarction

作　　者：李祯[1] 张之芬[1] 韩静颖 刘天璞 李丽[1] 鞠瑛[1] LI Zhen;ZHANG Zhi-fen;HAN Jing-ying(Laboratory Department,Shandong Provincial Hospital of Shandong University,Jinan 250021)

机构地区：[1]山东大学附属省立医院医学检验部,250021

出　　处：《临床输血与检验》2018年第6期625-628,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：国家自然科学基金(81000731);山东省优秀中青年科学家奖励基金(B2010YY045)资助

摘　　要：目的探讨脑梗死患者红细胞分布宽度(red cell distribution width,RDW)水平的变化及临床应用。方法收集265例脑梗死患者和160例健康对照组外周血,检测脑梗死组和健康对照组RDW水平,利用受试者工作特征曲线确定RDW最佳截点并将脑梗死患者分为低RDW-CV组(RDW<12.65%)和高RDW组(RDW≥12.65%),分析两组间年龄、性别、活化部分凝血酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(d-dimer,D-D)差异。结果脑梗死患者RDW水平显著高于健康对照组,差异有统计学意义(Z=–6.518,P <0.001);采用ROC曲线,将患者分为低RDW-CV组(RDW<12.65%)和高RDW-CV组(RDW≥12.65%),高RDW组患者的APTT、PT水平显著高于低RDW组(APTTZ=–2.331,P=0.020;PT Z=–2.062,P=0.039),而D-D水平差异无统计学意义(Z=–1.141,P=0.254)。结论脑梗死患者的RDW水平显著高于健康对照者,高RDW组APTT、PT水平显著升高提示RDW在脑梗死疾病辅助诊断中有重要意义。Objective To investigate the change and clinical application of the red cell distribution width（RDW）in diagnosis of cerebral infarction. Methods Peripheral blood was collected from 265 patients with cerebral infarction and160 healthy controls and the level of RDW was detected .The recipients operating characteristic curve （ROC curve） wasused to determine the best cutoff point of RDW.The patients were divided into low RDW（RDW〈12.65%） and high RDWgroups（RDW≥1 2 .6 5%）according to ROC curve. The variation of age,gender,activated partial thromboplastin time（APTT）,prothrombin time （PT）,and D-dimer （D-D） between the two groups were analyzed. Results The RDWlevel of the patients with cerebral infarction was obviously higher than that of the healthy control （Z=–6.518,P 〈0.001）.The value of APTT and PT in high RDW group （RDW≥12.65%） was higher （APTT Z=–2.331,P =0.020）than in lowRDW group（RDW〈12.65%,PT Z=–2.062,P =0.039）. But no significant difference was noted of D-D level between lowand high RDW groups （Z=–1.141,P =0.254）. Conclusion The RDW level were increased in the cerebral infarction patientsand APTT and PT were elevated,suggesting the role of RDW in the auxiliary diagnosis of cerebral infarction.

关 键 词：脑梗死 红细胞分布宽度 ROC曲线 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R331.141[医药卫生—临床医学]