血红素氧合酶1与急性脑梗死患者病情严重程度的相关性  

Correlation between heme oxygenase-1 and the severity in patients with acute cerebral infarction

作　　者：李土明[1] 钟萍[1] 王潇 吴滢[1] 童舒雯 Li Turning;Zhong Ping;Wang Xiao;Wu Ying;Tong Shuweng(Department of Neurology,Shanghai TCM-Integrated Hospital,Shanghai 200082,China)

机构地区：[1]上海市中西医结合医院神经内科,200082

出　　处：《中国脑血管病杂志》2018年第10期511-515,共5页Chinese Journal of Cerebrovascular Diseases

基　　金：上海市科学技术委员会科研计划(17401933100);上海市卫生和计划生育委员会科研课题(201540207);上海市虹口区卫生和计划生育委员会医学科研课题(虹卫1703-09)

摘　　要：目的探讨血清血红素氧合酶1(HO-1)水平与急性大动脉粥样硬化性脑梗死患者病情严重程度的相关性。方法回顾性连续纳入2016年1月至2017年12月上海市中西医结合医院神经内科急性大动脉粥样硬化性脑梗死住院患者107例为脑梗死组(首次发病且发病时间≤72 h)。选择同期体检健康者108例为对照组。记录并对比两组研究对象的基线资料及实验室检查结果,包括性别、年龄、高血压病、糖尿病、入院时美国国立卫生研究院卒中量表(NIHSS)评分、血脂、空腹血糖、HO-1水平等。根据脑梗死组患者基线NIHSS评分,将病情严重程度分为轻度(<5分)、中度(5～15分)、重度(≥16分),并比较病情严重程度间HO-1水平的差异。分析病情严重程度与HO-1水平的相关性。结果 (1)脑梗死组高血压病、糖尿病、吸烟史比例高于对照组,组间差异均有统计学意义(均P<0.05);年龄、性别、冠心病史、饮酒史的组间差异均无统计学意义(均P>0.05)。(2)脑梗死组血清HO-1水平明显高于对照组,组间差异有统计学意义[(10.4±4.0)μg/L比(3.5±1.5)μg/L,P<0.01]。(3)轻、中、重度急性脑梗死患者HO-1水平分别为(8.3±2.3)、(1 0.0±3.5)、(13.7±4.2)μg/L,组间差异有统计学意义(F=23.6,P<0.01)。(4)NIHSS评分与H0-1水平呈中度正相关(r=0.4936,P<0.01)。结论急性大动脉粥样硬化性脑梗死患者病情严重程度越重,HO-1水平越高。Objective To investigate the correlation between the heme oxygenase-1（ HO-1） level and the severity in patients with acute large atherosclerotic cerebral infarction. Methods From January 2016 to December 2017,107 consecutive inpatients with acute large atherosclerotic cerebral infarction（ cerebral infarction group） admitted to the Department of Neurology,Shanghai TCM-Integrated Hospital were enrolled retrospectively. They were the first onset and the onset time was ≤72 h. A total of 108 healthy persons were selected as control group in the same period. The baseline data and laboratory findings of the two groups were recorded and compared,including gender,age,hypertension,diabetes,National Institutes of Health Stroke Scale（ NIHSS） scores on admission,blood lipids,fasting blood glucose,and HO-1 levels. According to the baseline NIHSS score of the patients in the cerebral infarction group,the severity of disease was divided into mild（ 5）,moderate（ 5-15） and severe（ ≥16）,and the difference of HO-1 levels between the severity of disease was compared. The correlation between the severity of disease and the HO-1 level were analyzed. Results（ 1） The proportion of hypertension,diabetes mellitus,and smoking history in the cerebral infarction group was higher than that in the control group. The difference was statistically significant（ all P 0. 05）. There were no significant differences in age,sex,history of coronary heart disease,and drinking history（ all P 〈0. 05）.（ 2） The HO-1 level of the cerebral infarction group was significantly higher than that of the control group. There was significant difference between the groups（ 10. 4 ± 4. 0 μg/L vs. 3. 5 ± 1. 5 μg/L,P〈 0. 01）.（ 3） The levels of HO-1 in patients with mild,moderate and severe acute cerebral infarction were 8. 3 ± 2. 3,10. 0 ± 3. 5,and 13. 7 ± 4. 2 μg/L,respectively. The difference was statistically significant between the groups（ F = 23. 6,P 〈0. 01）.（ 4） The NIHSS score was positively mod

关 键 词：脑梗死 氧合酶类 血红素氧合酶-1 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]