自噬与神经系统疾病  

Autophagy and neuronal diseases

作　　者：杨小蕾 冉希 廖雪莲[2] 韩莉[2] 康焰[2] Yang Xiaolei;Ran Xi;Liao Xuelian;Han Li;Kang Yan(Department of Critical Care Medicine,Chongqing General Hospital,Chongqing 400013,China;Department of Critical Care Medicine,West China Hospital,Chengdu 610041,Sichuan,China)

机构地区：[1]重庆市人民医院重症医学科,400013 [2]四川大学华西医院重症医学科,四川成都610041

出　　处：《中华危重病急救医学》2018年第9期902-906,共5页Chinese Critical Care Medicine

基　　金：国家自然科学基金（81701880）;重庆市渝中区科委项目（20180142）

摘　　要：自噬是通过对衰老蛋白、受损细胞器消化降解再利用来维持细胞正常稳态的一个动态的过程。近年来随着学者对自噬研究的深入，发现自噬参与许多神经系统疾病的病理改变过程，并在其中发挥重要作用。本文就自噬在常见神经系统疾病的发病及其调控机制方面的相关研究进展进行综述，从而加深对自噬的了解，引起研究者对动态调控自噬及减轻自噬流损伤的关注。Autophagy is a dynamic process that allows recycling of long-lived proteins and damaged organelles into biosynthetic materials for maintaining the normal cellular homeostasis. Recently, accumulating evidence has indicated that autophagy played important roles in the pathogenesis of neuronal diseases. In this article, the research progress of autophagy in the pathogenesis and regulation mechanism of common nervous system diseases were reviewed to deepen the understanding of autophagy, and arouse researchers＇ attention on dynamic regulation of autophagy and alleviating autophagic flow injury.

关 键 词：自噬 神经系统疾病 神经退行性疾病 脑外伤 缺血性脑损伤 多发性硬化 

分 类 号：R741[医药卫生—神经病学与精神病学]