激光光纤介入的光动力疗法治疗皮肤鳞状细胞癌的实验研究  

A Study of Photodynamic Therapy for Squamous Cell Carcinoma by Using Laser Fiber Intervention

作　　者：李福民[1] 廖金凤[1] 刘伟[1] 陈明懿[1] Li Fumin;Liao Jinfeng;Liu Wei;Chen Mingyi(Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital,Chengdu 610072,Sichuan,China)

机构地区：[1]四川省医学科学院.四川省人民医院皮肤性病研究所,成都610072

出　　处：《肿瘤预防与治疗》2018年第5期331-335,共5页Journal of Cancer Control And Treatment

基　　金：四川省科技厅苗子课题(编号:2016063)

摘　　要：目的:评价激光光纤介入内照射5-氨基酮戊酸盐酸盐-光动力疗法(OFI-ALA-PDT)和传统外照射5-氨基酮戊酸盐酸盐-光动力疗法(ALA-PDT)治疗皮肤鳞状细胞癌的临床疗效及不良反应。方法:收集我院门诊48例鳞状细胞癌患者,随机分为光纤内照射组和传统外照射组。光纤内照射组在外用5-氨基酮戊酸盐酸盐后运用光纤插入靶皮损内,进行光动力治疗,而传统外照射组外用5-氨基酮戊酸盐酸盐后进行光动力治疗,观察两组患者的临床疗效、复发率以及不良反应。结果:光纤内照射组的临床疗效明显高于传统外照射组,差异有统计学意义(P <0. 05),复发率与传统外照射组相比差异无统计学意义(P> 0. 05),不良反应发生率低于传统外照射组,两者差异有统计学意义(P <0. 05)。结论:OFI-ALA-PDT治疗皮肤鳞状细胞癌疗效确切,美容效果佳,治疗高分化鳞状细胞癌尤其是年老体弱、美容要求高的患者亦有一定的疗效,且治疗过程中患者耐受性好,与ALA-PDT相比有一定优势。Objective： To evaluate the clinical effect and adverse reactions of the optical fiber irradiation 5-aminolevu- linic acid photodynamic therapy （OFI-ALA-PDT） and the traditional 5-aminolevulinic acid-photodynamic therapy （ALA- PDT） for squamous cell carcinoma. Methods： A total of 48 outpatients were randomly divided into two groups, one treated by OFI-ALA-PDT and the other treated by ALA-PDT, in which process clinical curative effect, adverse reactions as well as disease recurrence rate were observed respectively. Results： The clinical curative effect of OFI-ALA-PDT was noticeably higher than that of ALA-PDT （ P 〈 0.05 ）. The difference between two groups in recurrence rate was not statistically signifi- cant. The rate of adverse reactions of OFI-ALA-PDT was lower than that of ALA-PDT, which was of statistical significance （P 〈 0. 05 ）. Conclusion： The OFI-ALA-PDT does have positive effect in the treatment of squamous cell carcinoma. Meanwhile, OFI-ALA-PDT also has satisfactory cosmetic effect and is better tolerated in comparison with ALA-PDT.

关 键 词：鳞状细胞癌 5-氨基酮戊酸 光动力疗法 激光光纤 

分 类 号：R739.5[医药卫生—肿瘤] R454.2[医药卫生—临床医学]