姜黄素自微乳渗透泵控释片的制备  

Preparation of Curcumin Self-microemulsifying Osmotic Pump Control ed-release Tablet

作　　者：陈曦[1] 周敏[1] CHEN Xi, ZHOU Min Department of Pharmaceutical Engineering, Jiangsu Food and Pharmaceutical Science College(Huai＇an 22300)

机构地区：[1]江苏食品药品职业技术学院制药工程学院,淮安223005

出　　处：《食品工业》2018年第10期95-98,共4页The Food Industry

基　　金：淮安市重点研发计划(工业及信息化)(HAG2015020)

摘　　要：制备姜黄素自微乳渗透泵控释片,通过微孔渗透泵制剂控释难溶性药物的释放,以期提高姜黄素的生物利用度。通过三相图考察确定影响微乳形成区域面积的3个组分的种类及用量:油相、表面活性剂、助表面活性剂;通过单因素考察确定渗透泵控释片对药物释放影响较大的3个因素:促渗剂蔗糖的用量、包衣增重、致孔剂聚乙二醇PEG-400用量,并对优化处方进行释放拟合。结果表明,姜黄素自微乳的处方为:0.05 g姜黄素、0.40 g WL1349、0.45 g crempoher RH40、0.90 g甘油;控释片的促渗剂蔗糖用量30%,包衣增重3.5%, PEG-400 6 g。通过对制备处方的2, 4, 6, 8, 10和12 h的释放度的考察,发现该控释片12 h内的释放符合零级释放模型。自微乳渗透泵控释片可解决难溶性药物的控释制剂的设计要求。Through the preparation of cureumin self-microemulsifying osmotic pump controlled-release tablet and controlled- release insoluble drug, improve the bioavailability of cureumin. Through the construction of self-microemulsifying osmotic pump controlled-release tablet of curcumin, the quantitative determination using microemulsion chromatography method was done. Through ternary phase diagram, the three ingredients were determined, including oil, surfactant and co-surfactant. Through the single factor investigation, the three influencing factors were determined, including dosage of penetration enhancer sucrose, coating weight, and porogen PEG-400. The results showed that the formulation for cureumin self-microemulsion was curcumin 0.05 g, WL1349 0.40 g, crempoher RH40 0.45 g, glycerol 0.90 g. The tablet formulation was cane sugar 45%, coating weight 3%, acetone 400 mL, PEG-400 6 g. Based on the release of preparation of prescriptions in 2, 4, 6, 8, 10 and 12 h, the controlled-release tablet conformed to the zero-order release model. The self-microemulsifying osmotic pump tablet could solve the controlled-release of insoluble drugs.

关 键 词：姜黄素 自微乳 渗透泵控释片 生物利用度 

分 类 号：R283.6[医药卫生—中药学]