脂肪细胞胆固醇稳态与动脉粥样硬化  

Adipocyte cholesterol homeostasis and atherosclerosis

作　　者：杨金芝 孙晓东[1] 丁芳芳 赵颖[1] YANG Jinzhi;SUN Xiaodong;DING Fangfang;ZHAO Ying(Department of Pathology ＆ Pathophysiology,Soochow University,Suzhou,Jiangsu 215123,China)

机构地区：[1]苏州大学病理与病理生理学系

出　　处：《中国动脉硬化杂志》2018年第9期953-960,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81470564)

摘　　要：肥胖是动脉粥样硬化发展的重要危险因素。肥胖的发生伴随着脂肪细胞内胆固醇含量与分布的改变。胆固醇是细胞膜脂筏区的重要组成成分与调节因子。而且,它本身还是信号分子,可直接调控脂肪细胞的代谢与功能。脂肪细胞自身合成胆固醇的能力极其有限,因此主要依赖摄取与流出来调控胆固醇稳态。最新研究更发现阻断脂肪细胞上胆固醇的主动流出可抑制肥胖的发生。本文将详细介绍脂肪细胞摄取与外排胆固醇的通路,并讨论胆固醇稳态对脂肪细胞的重要性及脂肪细胞胆固醇稳态在动脉粥样硬化发展中的作用。As an important risk factor for the development of atherosclerosis,the occurrence of obesity is accompanied by changes in cholesterol content and distribution in adipocytes. Cholesterol is an essential component and regulator of lipid rafts in cell membrane. Moreover,it itself is a signaling molecule,which can directly regulate the metabolism and function of adipocytes. The ability of adipocytes to synthesize cholesterol is very limited,so they rely mainly on uptake and flow to regulate cholesterol homeostasis. Recent studies have found that blocking the active efflux of cholesterol on fat cells can inhibit the occurrence of obesity. This article will detailedly describe the cholesterol uptake and efflux pathways of adipocytes,and elucidate the importance of cholesterol homeostasis for adipocytes and the role of adipocyte cholesterol homeostasis in the development of atherosclerosis.

关 键 词：脂肪细胞 胆固醇稳态 胆固醇外流 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]