脂肪分化相关蛋白对泡沫细胞形成中脂质蓄积的影响  

Effect of adipose differentiation-related protein on lipid accumulation in foam cell formation

作　　者：张瑞 李晓歌 袁旭 郭东铭[1] 袁中华[1] ZHANG Rui;LI Xiaoge;YUAN Xu;GUO Dongming;YUAN Zhonghua(Institute of Cardiovascular Disease ＆ Key Laboratory for Arteriosclerology of Hunan Province,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室

出　　处：《中国动脉硬化杂志》2018年第9期966-972,共7页Chinese Journal of Arteriosclerosis

基　　金：湖南省青年基金资助项目(2018JJ3459)

摘　　要：动脉粥样硬化是一种常见的心血管代谢性疾病,它的主要并发症心肌梗死与缺血性脑卒中已经成为世界首要的死因。泡沫细胞的形成在动脉粥样硬化的发生和发展中起到关键作用。这些细胞的产生与细胞内脂质蓄积密切相关。脂肪分化相关蛋白（PLIN2）能够促进细胞内脂质蓄积。本文主要阐述在泡沫细胞形成中,PLIN2对于脂质蓄积的影响,为动脉粥样硬化防治提供新的思路。Atherosclerosis is a common cardiovascular metabolic disease,and its main complications,myocardial infarction and ischemic stroke,have become the first cause of death in the world. The formation of foam cells plays a key role in the development and progression of atherosclerosis. The production of these cells is closely related to intracellular lipid accumulation. Adipose differentiation-related protein（PLIN2） can promote intracellular lipid accumulation. This article mainly discusses the effect of PLIN2 on lipid accumulation in the formation of foam cells,providing new ideas for the prevention and treatment of atherosclerosis.

关 键 词：脂肪分化相关蛋白 泡沫细胞 脂质蓄积 动脉粥样硬化 

分 类 号：R363[医药卫生—病理学]