阿瑞匹坦预防化疗诱导恶心呕吐的疗效分析  

Curative Effect of Aprepitant Preventing CINV

作　　者：关莎莎[1] 张丽沙[1] 钟殿胜[1] 马晴[1] 孟凡路[1] 邵宜[1] 于涛[1] 刘夏[1] Shasha GUAN;Lisha ZHANG;Diansheng ZHONG;Qing MA;Fanlu MENG;Yi SHAO;Tao YU;Xia LIU(Department of Medical Oncology,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院肿瘤科,天津300052

出　　处：《中国肺癌杂志》2018年第10期800-804,共5页Chinese Journal of Lung Cancer

摘　　要：背景与目的化疗是治疗恶性肿瘤最重要的手段,然而化疗诱导的恶心呕吐对患者影响深远。近些年来,不断有新的止吐药物问世,如阿瑞匹坦。我们回顾性分析了2014年8月-2016年12月使用含高度致吐药顺铂化疗方案的肿瘤患者中,阿瑞匹坦联合托烷司琼、地塞米松预防化疗诱导呕吐(chemotherapy-induced nausea and vomiting, CINV)的效果。方法在使用含高度致吐药顺铂化疗方案的肿瘤患者中,应用阿瑞匹坦联合托烷司琼、地塞米松的止吐方案,观察期分为整体观察期:化疗后0 h-120 h;急性呕吐观察期:化疗0 h-24 h;延迟性呕吐观察期:化疗后24 h-120 h。观察目标包括完全应答(complete response, CR)和完全预防(complete protection, CP)。结果整体观察期的CR为86.02%,急性呕吐观察期和延迟性呕吐观察期分别为89.25%、87.1%;CP分别为46.22%、83.87%、45.16%。止吐效果与年龄分布关系具有显著性(P=0.008)。结论阿瑞匹坦联合托烷司琼、地塞米松的方案可有效预防使用含高度致吐药顺铂化疗方案的肿瘤患者中CINV的发生,提高患者的生活质量和化疗的依从性。Background and objective Chemotherapy is the most important method for cancer treatment. How- ever, chemotherapy induced nausea and vomiting （CINV） has a profound effect on patients. In recent years, there have been new antiemetic drugs, such as aprepitant. We review the curative effect of aprepitant with tropisetron and dexamethasone for prevention of nausea and vomiting in patients receiving Cisplatin chemotherapy. Methods Observation is divided into three stages. Whole study phase （0-120 h after chemotherapy administration）, acute phases （0-24 h）, and delayed phase （24 h-120 tl）. The primary endpoints were complete response （CR） and complete prevention （CP） during the three different study phase. Results In the whole study phase, 86.02% of patients achieved CR; in acute phases and delayed phases were 89.25%, 87.1%, respectively. CP were 46.22%, 83.87%, 45.16%, respectively. Anti-CINV effect was significantly associated with age distribution （P=0.008）. Conclusion Aprepitant with tropisetron and dexamethasone prevented effectively CNIV for patients receiving Cisplatin chemotherapy. This combination could improve the quality of life and the compliance of patient with chemotherapy.

关 键 词：阿瑞匹坦 癌症 化疗诱导的恶心呕吐 顺铂 

分 类 号：R730.53[医药卫生—肿瘤]