硫杂蒽酮类化合物合成方法学研究  

Study on synthetic methodology of thioxanthones

作　　者：胡新龙 卢俊瑞[1] 廉景燕[1] 谢志强 卢博为 刘金彪[1] HU Xin-long;LU Jun-rui;LIAN Jing-yan;XIE Zhi-qiang;LU Bo-wei;LIU Jin-biao(School of Chemistry and Chemical Engineering,Tianjin University of Technology,Tianjin 300384,China;Tianjin Ruiling Chemical Engineering Co.,Ltd.,Tianjin 300384,China;Sehool of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津理工大学化学化工学院,天津300384 [2]天津瑞岭化工有限公司,天津300384 [3]天津大学化工学院,天津300072

出　　处：《天津理工大学学报》2018年第5期52-55,共4页Journal of Tianjin University of Technology

基　　金：国家自然科学基金(21476174;21176194)

摘　　要：本文以邻氯苯腈和取代芳基硫酚为原料,经醚化反应、环合反应合成了8种不同取代的硫杂蒽酮类化合物.在醚化反应过程中使用了对反应体系有较好溶解性的非质子极性溶剂,极大地加快了反应速度,醚化反应收率可达84～95%,两步总收率50%～72%.此方法克服了传统合成方法中浓硫酸作溶剂造成的副反应以及浓硫酸使用过多对环境造成的污染.In this paper,8 different substituted thioxanthones were synthesized by 2-chlorobenzonitrile and substituted arylthiophenols via etherification and cyclization. In the process of etherification,the aprotic polar solvent with good solubility in the reaction system was used,which greatly accelerated the reaction rate. The yield of etherification reaction reached 84%~95% and the total yield in two steps was 50%~72%. This method overcomes the side reactions caused by the concentrated sulfuric acid as a solvent in traditional synthesis methods and the pollution caused by excessive use of concentrated sulfuric acid on the environment.

关 键 词：芳基硫酚 硫杂蒽酮类化合物 醚化反应 环合反应 

分 类 号：O643.11[理学—物理化学]