银杏叶胶囊联合尼莫同片治疗脑小血管病性认知功能障碍48例临床观察  

Clinical Observation of Gingko Leaf Capsules Combined with Nimodipine Tablets for 48 Cases of Cognitive Impairment Induced by Cerebral Small Vessel Disease

作　　者：何昕[1] HE Xin

机构地区：[1]濮阳市安阳地区医院神经内科,河南安阳455000

出　　处：《新中医》2018年第10期62-65,共4页New Chinese Medicine

摘　　要：目的:观察银杏叶胶囊联合尼莫同片治疗脑小血管病(CSVD)性认知功能障碍瘀血阻络证的疗效及对血清中同型半胱氨酸(Hcy)水平的影响。方法:选取CSVD致认知功能障碍患者96例,按随机数字表法分为治疗组和对照组,各48例。对照组口服尼膜同片,治疗组在对照组基础上口服银杏叶胶囊,2组连续治疗3个月。比较2组简明精神状态量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、瘀血阻络证症状评分及临床疗效。检测2组血清中Hcy水平。结果:治疗组的总有效率为93.75%,显著高于对照组75.00%,差异有统计学意义(P <0.05)。治疗后,2组MMSE和MoCA评分显著升高,瘀血阻络证症状评分显著降低,血清中Hcy水平明显降低,差异均有统计学意义(P <0.01)。治疗后,治疗组MMSE和MoCA评分显著高于对照组,瘀血阻络证症状评分显著低于对照组;治疗后6周和12周,治疗组血清中Hcy水平显著低于同期对照组,差异均有统计学意义(P <0.01)。结论:银杏叶胶囊联合尼莫同片治疗CSVD认知功能障碍瘀血阻络证疗效确切,下调患者血清中Hcy水平可能是其作用机制之一。Objective： To observe the clinical effect of Gingko Leaf capsules combined with nimodipine tablets for cognitive impairment with syndrome of collateral retardation due to blood stasis induced by cerebral small vessel disease（CSVD）,and its effect on the level of homocysteine（Hcy） in serum. Methods： Selected 96 cases of patients with cognitive impairment induced by CSVD, and divided them into the treatment group and the control group randomly, 48 cases in each group. The control group received the oral administration of nimodipine tablets, while the treatment additionally received the oral administration of Gingko Leaf capsules. The treatment for both groups lasted for 3 months. Compared the scores of the mini-mental state examination（MMSE）,scores of Montreal cognitive assessment（MoCA）,symptom scores of syndrome of collateral retardation due to blood stasis,and the clinical effect in both groups. Detected the levels of Hcy in serum of both groups. Results： The total effective rate was 93.75% in the treatment group and 75.00% in the control group,difference being significant（P〈0.05）. After treatment,the scores of MMSE and MoCA were significantly increased in both groups,symptom scores of syndrome of collateral retardation due to blood stasis were significantly decreased,and the levels of Hcy were significantly decreased,differences being significant（P〈0.01）. After treatment,the scores of MMSE and MoCA in the treatment group were evidently higher than those in the control group,and symptom scores of syndrome of collateral retardation due to blood stasis were evidently lower than those in the control group;after treatment for 6 weeks and 12 weeks,the level of Hcy in the treatment group was evidently lower than that in the control group in the same periods respectively, differences being significant（P〈0.01）. Conclusion： The application of Gingko Leaf capsules combined with nimodipine tablets has definite effect in treating cognitive impairment with syndrome of collateral retard

关 键 词：脑小血管病(CSVD) 认知功能障碍 银杏叶胶囊 瘀血阻络证 简明精神状态量表(MMSE) 蒙特利尔认知评估量表(MoCA) 同型半胱氨酸(Hcy) 

分 类 号：R749.1[医药卫生—神经病学与精神病学]