化瘀散结法联合屈螺酮炔雌醇预防子宫内膜息肉术后复发的临床研究  

Clinical Research on Therapy of Removing Blood Stasis and Dispersing Mass Combined with Drospirenone Ethinyl Estradiol in Preventing Postoperative Recurrence of Endometrial Polyps

作　　者：张宜群 赵珊琼 ZHANG Yiqun;ZHAO Shanqiong

机构地区：[1]宁波市中医院妇科,浙江宁波315000

出　　处：《新中医》2018年第10期124-126,共3页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2015ZB101)

摘　　要：目的:观察化瘀散结法联合屈螺酮炔雌醇预防子宫内膜息肉术后复发的临床效果。方法:将宫腔镜下子宫内膜息肉电切术患者80例作为研究对象,按照随机数字表法分为2组各40例,激素组患者给予屈螺酮炔雌醇片口服治疗,联合组予屈螺酮炔雌醇片联合化瘀散结法中药治疗;2组患者均连续治疗3个月经周期,并随访至术后6月,比较2组患者治疗前后子宫内膜厚度,术后复发率以及治疗过程中不良反应。结果:术后1周后,联合组患者子宫内膜厚度值大于激素组,但2组比较,差异无统计学意义(P>0.05);术后6月,联合组患者子宫内膜厚度值明显大于激素组,差异有统计学意义(P <0.05)。不良反应发生率激素组为20.0%,联合组为15.0%,2组比较,差异无统计学意义(P> 0.05)。息肉复发率激素组为20.0%,联合组为5.0%,2组比较,差异有统计学意义(P <0.05)。结论:化瘀散结法联合屈螺酮炔雌醇防治子宫内膜息肉术后复发疗效显著,且不增加不良反应发生风险。Objective： To observe the clinical effect of therapy of removing blood stasis and dispersing mass combined with drospirenone ethinyl estradiol in preventing postoperative recurrence of endometrial polyps. Methods：Selected 80 patients who received electrocision for endometrial polyps under hysteroscope as study subjects and divided them into two groups according to the random number table,40 patients in each group. The hormone group was given the oral administration of drospirenone ethinyl estradiol tablets,while the combination group was given drospirenone ethinyl estradiol tablets combined with Chinese medicine treatment of the therapy of removing blood stasis and dispersing mass. The treatment for patients in the two groups lasted for 3 menstrual cycles with a follow-up for6 months. Compared the endometrial thickness before and after treatment, postoperative recurrence rate and adverse reactions during treatment in the two groups. Results：One week after operation,the endometrial thickness in the combination group was bigger than that in the hormone group,but there was no significant difference being found in the comparison of the two groups（P〉0.05）. Six months after operation,the endometrial thickness in the combination group was significantly greater than that in the hormone group,difference being significant（P〈0.05）. The incidence of adverse reactions was 20.0% in the hormone group and 15.0% in the combination group,but there was no significant difference being found in the comparison of the two groups（P〉0.05）. The incidence of polyps was 20.0% in the hormone group and 5.0% in the combination group,difference being significant（P〈0.05）. Conclusion：The application of therapy of removing blood stasis and dispersing mass combined with drospirenone ethinyl estradiol has evident curative effect in preventing postoperative recurrence of endometrial polyps without increasing the risk of adverse reactions.

关 键 词：子宫内膜息肉 术后复发 化瘀散结法 屈螺酮炔雌醇 宫腔镜 

分 类 号：R737.33[医药卫生—肿瘤]