网络游戏障碍青少年执行Stroop任务的脑功能磁共振成像研究  

A functional magnetic resonance imaging study of the Stroop effect in adolescents with internet gaming disorder

作　　者：周于 向慧[2] 陈洁宇 李心怡 王涛[3] 李武超 刘远成 翟茂雄[3] Zhou Yu;Xiang Hui;Chen Jieyu;Li Xinyi;Wang Tao;Li Wuchao;Liu Yuaneheng;Zhai Maoxiong(Department of Medical Psychology,Medical Humanities College,Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学医学人文学院医学心理学教研室,550004 [2]贵州省人民医院心理科 [3]贵州省人民医院放射科

出　　处：《中华精神科杂志》2018年第5期329-334,共6页Chinese Journal of Psychiatry

基　　金：贵州省留学人员科技创新项目[黔人项目资助合同（2015）06];贵州省人民医院博士基金（GZSYBS[2016]06）;贵州省科技计划项目（黔科合基础[2018]1101）

摘　　要：目的 探索网络游戏障碍（internet gaming disorder,IGD）青少年执行Stroop任务时的大脑激活情况.方法 采用fMRI对10例IGD青少年（IGD组）和10名网络游戏娱乐使用（recreational internet game users,RGU）青少年（RGU组）执行Stroop任务时的大脑进行扫描,测查该条件下2组被试者的反应时和正确率以及全脑激活情况,采用描述性分析和f检验等统计学方法对反应时和正确率进行分析,采用SPM8对fMRI图像进行分析.结果 （1）IGD组在执行一致色词Stroop任务的反应时长于RGU组[（707.7±56.1）ms比（632.1±83.5）ms;t=2.38,P=0.031],执行不一致色词的正确率小于RGU组[（60.2±17.5）％比（79.0±19.5）％;t=-2.27,P=0.034];（2）在不一致条件下,IGD组双侧小脑后叶,左侧颞上回、前额叶、丘脑、中央前回和额中回,右侧扣带回的脑区激活低于RGU组（峰值强度为-4.11～-5.13,P＜0.05,AlphaSim校正）;在一致条件下,IGD组右侧小脑前叶、颞上回和前额叶,左侧脑岛的脑区激活低于RGU组（峰值强度为-3.84～-4.72,P＜0.05,AlphaSim校正）;Stroop效应（不一致-一致）下IGD组左侧中央前回、楔前叶和中央旁小叶的脑区激活低于RGU组（峰值强度为-3.94,-5.49,P＜0.05,AlphaSim校正）.结论 IGD青少年在Stroop任务中反应时更长,错误更多,额叶、扣带回、颞叶、丘脑、楔前叶、小脑等脑区的激活异常.Objective To investigate the brain activation at the Stroop task in a group of adolescents diagnosed as the internet gaming disorder （IGD）.Methods 10 IGD adolescents and 10 adolescent recreational internet game users （RGU） completed a functional magnetic resonance imaging （fMRI） Stroop task.The response time and accuracy of the two groups and the whole brain activation were measured.The differences between the two groups in response time and accuracy were assessed by t test,and the fMRI data was analyzed by SPM8.Results （1） Compared with the RGU group,the response time in congruent （CC） stimulus was longer （（707.7± 56.1） ms vs.（632.1 ± 83.5） ms;t=2.38,P=0.031） and the accuracy to incongruent （IC） stimulus was less（（60.2± 17.5）% vs.（79.0± 19.5）%;t=-2.27,P=0.034） in IGD group;（2） During IC stimulus,compared to RGU group,the neural activation in IGD group significantly decreased in the bilateral cerebellum posterior lobe,left superior temporal gyrus,left prefrontal lobe,left thalamus,left precentral gyrus,left middle frontal gyrus and the right cingulate gyrus （Peak value=-4.11--5.13,P〈0.05,AlphaSim corrected）.And the IGD group showed less activation during the CC stimulus in right cerebellum anterior lobe,right superior temporal gyrus,right prefrontal lobe and left insula （Peak value=-3.84--4.72,P〈0.05,AlphaSim corrected）.During the Stroop effect （IC-CC）,IGD group showed significantly less activation in left precentral gyrus,left precuneus lobe,and left paracentral lobule （Peak value=-3.94,-5.49,P〈0.05,AlphaSim corrected）.Conclusion IGD adolescents have poor Stroop performance in response time and accurate rate,which might be correlated to the abnormal activation of their dysfunctional brain regions,such as the frontal lobe,cingulate cortex,temporal lobe,thalamus,precuneus,and the cerebellum.

关 键 词：青少年 磁共振成像 网络游戏障碍 STROOP任务 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.99[医药卫生—诊断学]