复合性宫颈小细胞癌12例的临床病理分析  

Compound small cell carcinoma of the cervix: a clinicopathologic analysis of 12 cases

作　　者：李玲[1] 何银珠[2] 朱伟峰[2] 张红[2] 陈刚[2] 周冬梅[2] LI Ling;HE Yin-zhu;ZHU Wei-feng;ZHANG Hong;CHEN Gang;ZHOU Dong-mei(Department of Gynaecological Oneology;Department of Pathology,Fujian Cancer Hospital,Fujian Medical University Cancer Hospital,Fuzhou,Fujian 350014,China)

机构地区：[1]福建省肿瘤医院福建省医科大学附属肿瘤医院肿瘤妇科,福州350014 [2]福建省肿瘤医院福建省医科大学附属肿瘤医院病理科,福州350014

出　　处：《诊断病理学杂志》2018年第10期702-705,709,共5页Chinese Journal of Diagnostic Pathology

基　　金：福建省卫生系统中青年骨干人才培养项目(编号:2015-ZQN-JC-8);国家临床重点专科建设项目

摘　　要：目的分析复合性宫颈小细胞癌的临床和病理特征,提高诊断和鉴别诊断水平,增加对其认识。方法收集12例复合性宫颈小细胞癌的临床和病理资料,结合免疫组织化学分析其组织形态学特点、诊断及鉴别诊断要点。结果 12例患者均以阴道出血为主诉,中位发病年龄48.3岁,平均生存时间是23.1个月。病理特点为小细胞癌成分合并原位或浸润性的腺癌或鳞癌成分,发病时多已侵犯宫颈间质深层,小细胞癌成分示免疫组化染色Syn、Cg A、CD56弥漫(+)。治疗选择手术及放、化疗。结论复合性宫颈小细胞癌预后差,确诊依靠组织形态学和免疫组织化学结果。目前治疗方案及预后影响因素尚无统一定论。Objective To improve the diagnosis and differential diagnosis of compound small cell carcinoma of the cervix（ SCCC） by analysis of the clinical and pathologic characteristics. Methods 12 cases of compound small cell carcinoma of the cervix were collected and immuohistochemical stain was carried out. Results SCCC was combined with adenocarcinoma or squamous cell carcinoma,invasive or in situ,and cervical stroma had always been infringed deeply in12 cases,with vaginal bleeding as chief complaint; the median onset age was 48. 3 years and average survival time was23. 1 months. Immunohistochemical stains showed that the SCCC cells were diffusely positive for Syn,Cg A and CD56.Surgery,radiation and chemotherapy could be chosen. Conclusions Compound small cell carcinoma of the cervix has a poor prognosis. Its diagnosis would be confirmed on morphological features and immunohistochemical results. There is no unified conclusion about treatment plan and prognosis-influencing factors currently.

关 键 词：宫颈 复合性 小细胞癌 诊断 治疗 预后 

分 类 号：R737.33[医药卫生—肿瘤]