甲状腺乳头状癌合并桥本甲状腺炎患者的临床特征和预后分析  

Clinical characteristics and prognosis of patients with papillary thyroid carcinoma combined with Hashimoto's thyroiditis

作　　者：李建[1] 樊华[1] 贺晓斌[1] 李晓勇[1] LI Jian;FAN Hua;HE Xiaobin;LI Xiaoyong(Department of Glandular Vascular Surgery,Affiliated Hospital of Yan＇an University,Yan＇an 716000,Shaanxi,China)

机构地区：[1]延安大学附属医院腺体血管外科,陕西延安716000

出　　处：《癌症进展》2018年第10期1242-1244,1317,共4页Oncology Progress

摘　　要：目的探讨甲状腺乳头状癌(PTC)合并桥本甲状腺炎(HT)患者的临床特征及预后情况。方法选取326例经手术治疗后并病理确诊为PTC的初治患者,按照是否合并HT进行分组,将PTC合并HT患者作为观察组(n=64),将单纯PTC患者作为对照组(n=262),分析两组患者的临床资料,比较分析两组患者的临床特征及预后情况。结果单因素分析结果显示,两组患者的年龄、性别、肿瘤直径、中央区淋巴结转移发生率、术前B超微小钙化发生率比较,差异均有统计学意义(P﹤0.05);多因素分析结果显示,年龄、性别、中央区淋巴结转移、合并HT是患者预后的影响因素。观察组患者无淋巴结复发,残余对侧甲状腺叶复发1例,对照组患者淋巴结复发18例,残余对侧甲状腺叶复发10例,观察组预后情况优于对照组,差异有统计学意义(P﹤0.05)。结论 HT与PTC关系密切,年龄、性别、中央区淋巴结转移、合并HT是PTC患者预后的独立影响因素,相比单纯PTC,PTC合并HT患者预后情况较好。Objective To investigate the clinical characteristics and prognosis of patients with papillary thyroid carcinoma（PTC） combined with Hashimoto＇s thyroiditis（HT）. Method Three hundreds and twenty-six patients who underwent surgical treatment and were pathologically diagnosed as PTC were investigated. According to whether combined with HT, the PTC patients with HT were divided into observation group（n=64）, and the patients with simple PTC were divided into control group（n=262）. The clinical data of the selected patients were respectively analyzed and the clinical characteristics and prognosis of patients in the two groups were compared. Result Univariate analysis showed that there are significant differences in age, sex, diameter of tumor, incidence rate of central lymph node metastasis, incidence rate of microcalcification on B-mode ultrasound before treatment between two groups（P〈0.05）. Multivariate analysis showed that age, sex, central lymph node metastasis, and combination of HT were influence factors. In the observation group,there was no patients with lymph node recurrence, but 1 patient suffered residual recurrence on the side of thyroid lobe; in control group, there were 18 patients with lymph node recurrence and 10 cases of residual recurrence on the side of thyroid lobe. The prognosis of the observation group was better than that of the control group, and the difference was statistically significant（P〈0.05）. Conclusion HT is closely related to PTC and the age, sex, central lymph node metastasis and combination of HT are the influence factors of patients. The prognosis of PTC patients with HT is better compared with PTC alone.

关 键 词：甲状腺乳头状癌 桥本甲状腺炎 临床特征 预后分析 

分 类 号：R736.1[医药卫生—肿瘤]