3,4-二氢嘧啶-2-(硫)酮类化合物的合成  

Synthesis of 3,4-Dihydropyrimidin-2-(Thio) one Derivatives

作　　者：李公春[1] 侯旭锋[1] 刘文静 LI Gongchun;HOU Xufeng;LIU Wenjing(Key laboratory of Chemo/Biosensing and Detectio;College of Chemistry and Chemical Engineering,Xuchang University,Xuchang 461000,China)

机构地区：[1]许昌学院化学化工学院化学生物传感与检测重点实验室,河南许昌461000

出　　处：《许昌学院学报》2018年第10期43-46,共4页Journal of Xuchang University

摘　　要：以无水乙醇为溶剂,氨基磺酸作为催化剂,以芳香醛、乙酰乙酸乙酯和脲(硫脲)为原料进行三组分反应,通过Biginelli反应合成了10个3,4-二氢嘧啶-2-(硫)酮类化合物.该方法具有反应条件温和,操作简单,污染少,环境友好等特点.Ten derivatives of 3, 4-dihydropyrimidin-2-（thio）one were synthesized by urea （thiourea）, ethyl acetoacetate and aromatic aldehydes by using sulfamic acid as catalyst and anhydrous alcohol as solvent via Biginelli reaction.The method has the advantages of mild reaction conditions, simple operation, less pollution and friendly environment.

关 键 词：BIGINELLI反应 3 4-二氢嘧啶-2-(硫)酮 芳香醛 合成 

分 类 号：O626.41[理学—有机化学]