米诺环素在侵袭性牙周炎治疗中的应用  

Application of minocycline in the treatment of aggressive periodontitis

作　　者：贺克全[1] 张俊健[1] He Kequan;Zhang Junjian(Department of Stomatology,the Peopled Hospital of Panan County,Zhejiang 322300,China)

机构地区：[1]浙江省磐安县人民医院口腔科,322300

出　　处：《中国基层医药》2018年第19期2467-2470,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省医药卫生科技计划一般项目（2013KYA220）

摘　　要：目的 探讨米诺环素在侵袭性牙周炎治疗中的应用效果.方法 选择磐安县人民医院2014年1月至2017年1月收治的侵袭性牙周炎患者116例为研究对象,依照治疗方法不同分为观察组和对照组各58例,对照组采用基础治疗,观察组在对照组基础上采用米诺环素治疗.观察两组临床疗效,比较两组肿瘤坏死因子（TNF-α）、白细胞介素17（IL-17）、基质金属蛋白酶1（MMP-1）、基质金属蛋白酶8（MMP-8）的水平及牙龈指数（GI）、牙周探诊深度（PD）、附着丧失（AL）、牙周炎龈沟液（NO）的变化.结果 治疗后,观察组总有效率为93.1％（58/54）,明显高于对照组的80.0％（58/46）,差异有统计学意义（χ2=9.469,P=0.002）;治疗后,观察组龈沟液TNF-α、IL-17、MMP-1、MMP-8分别为（2.98±0.77）ng/mL、（20.87±5.34）pg/mL、（1422.45±175.45）pg/mL、（1341.58±169.56）pg/mL,GI、PD、AL、NO分别为（1.21±0.38）mm、（1.51±0.61）mm、（2.43±0.39）mm、（45.78±8.21）μmol/L,对照组TNF-α、IL-17、MMP-1、MMP-8分别为（3.98±0.99）ng/mL、（31.65±7.88）pg/mL、（1781.44±199.55）pg/mL、（1678.99±185.44）pg/mL,GI、PD、AL、NO分别为（3.31±0.29）mm、（4.21±0.89）mm、（3.59±0.62）mm、（64.34±12.88）μmol/L,与治疗前比较,两组龈沟液TNF-α、IL-17、MMP-1、MMP-8水平较均明显降低（观察组：t=14.590、18.885、23.019、3.789,对照组：t=7.809、12.993、10.905、7.608,均P〈0.05）,与对照组比较,观察组龈沟液TNF-α、IL-17、MMP-1、MMP-8及GI、PD、AL、NO水平较低（t=6.072、8.625、10.289、10.226、33.4572、19.057、12.061、9.254,均P〈0.05）.结论 使用米诺环素治疗侵袭性牙周炎可明显降低龈沟液TNF-α、IL-17、MMP-1、MMP-8水平,缓解牙周菌斑,促进牙周组织再生长,具有显著的临床疗效.Objective To study the application effect of minocycline in the treatment of aggressive periodontitis.Methods From January 2014 to January 2017,116 cases of invasive periodontitis in the People＇s Hospital of Panan County were selected in the research.According to the different treatment methods,the patients were divided into observation group and control group with 58 cases in each group.The control group was given basic treatment,the observation group was given minocycline on the basis of basic treatment.The levels of tumor necrosis factor α（TNF-α）,interleukin-17（IL-17）,matrix metalloproteinase-1（MMP-1）and matrix metalloproteinase-8（MMP-8）in the two groups were observed.The changes of gingival index（GI）,periodontal exploration depth（PD）,attachment loss（AL）,periodontitis gingival crevicular fluid（NO）were compared.Results After treatment,the total effective rate in the observation group was 93.1%（58/54）,which was significantly higher than that in the control group [80.0%（58/46）],the difference was statistically significant（χ2 =9.469,P=0.002）.After treatment,the levels of TNF-α,IL-17,MMP-1,MMP-8 in the gingival crevicular fluid of the observation group were（2.98 ±0.77）ng/mL,（20.87 ± 5.34）pg/mL,（1422.45 ±175.45）pg/mL,（1341.58 ±169.56）pg/mL,respectively,which were lower than those of the control group[（3.98 ±0.99）ng/mL,（31.65 ±7.88）pg/mL,（1781.44 ±199.55）pg/mL,（1678.99 ± 185.44）pg/mL]（t=6.072,8.625,10.289,10.226,P〈0.05）.The levels of GI,PD,AL and NO of the observation group were（1.21 ±0.38）mm,（1.51 ±0.61）mm,（2.43 ±0.39）mm,（45.78 ±8.21）μmol/L,respectively,which were lower than those of the control group [（3.31 ±0.29）mm,（4.21 ±0.89）mm,（3.59 ±0.62）mm,（64.34 ± 12.88）μmol/L]（t=33.4572,19.057,12.061,9.254,all P〈0.05）.After treatment,the levels of TNF-α,IL-17,MMP-1 and MMP-8 in the gingival crevicular fluid of the two groups were significantly lower compared with those before treat

关 键 词：侵袭性牙周炎 肿瘤坏死因子or 白细胞介素17 基质金属蛋白酶1 基质金属蛋白酶8 米诺环素 

分 类 号：R781.42[医药卫生—口腔医学]