脑血管病的遗传流行病学研究  

A Case-control Study on the Genetic Epidemiology of Cerebrovascular Diseas

作　　者：柴永宏[1] 高敏[1] 焦玉壮 张敬军[1] CHAI Yong-hong;GAO Min;JIAO Yu-zhuang;ZHANG Jingojun(Department of Neurology,the Affiliated Hospital of Taishan Medical University,Taian 271000,China.)

机构地区：[1]泰山医学院附属医院神经内科,泰安271000

出　　处：《中国临床神经科学》2018年第5期514-522,共9页Chinese Journal of Clinical Neurosciences

基　　金：山东省高等学校科技计划项目(编号:J15LL07);国家级大学生创新创业训练计划项目(编号:20161043928)

摘　　要：目的探讨脑血管病发病过程中的遗传和环境因素,研究家族聚集性脑血管病的概念。方法收集130例确诊的大动脉粥样硬化性脑梗死(LAA)患者(LAA组)和130例脑出血患者(脑出血组);另选择260例非心脑血管病患者依据一级和二级家系亲属中脑血管病的发病情况分为LAA对照组(130例)和脑出血对照组(130例)。采用病例对照及遗传流行病学家系调查方法进行分析研究。结果 LAA组亲属的LAA患病率为5.77%, LAA对照组亲属为2.40%,两组间比较差异有显著统计学意义(P=0.000);脑出血组亲属脑出血患病率为6.75%,脑出血对照组亲属为2.57%,两组间比较差异有显著统计学意义(P=0.000)。LAA组配偶LAA患病率为4.62%,LAA对照组配偶LAA患病率为2.31%,两组间比较差异无显著性;脑出血组配偶脑出血患病率为2.31%,脑出血对照组配偶脑出血患病率为1.54%,两组间比较差异无显著性。LAA组一级和二级亲属遗传度分别为44.94%和18.81%;脑出血组一级和二级亲属遗传度分别为51.00%和38.75%。结论 LAA和脑出血有明显的家族聚集性,遗传因素是导致家族聚集性发生的重要原因之一。Aim To investigate the genetic and environmental factors of cerebrovascular diseases and the concept of familial aggregated cerebrovascular diseases. Methods 130 patients with large-artery atherosclerosis（LAA）（LAA group） and 130 patients of cerebral hemorrhage（cerebral hemorrhage group） were collected. Other 260 cases of non-cardiovascular disease were LAA control group（130 cases） and cerebral hemorrhage control group（130 cases）. The heritability of cerebrovascular disease was detected by the case-control and the family line investigative methods. Results The prevalence of LAA was 5.77% in relatives of group LAA and 2.40% in LAA control group. There was a significant difference between the two groups（P=0.000）. The prevalence of cerebral hemorrhage was 6.75% in the cerebral hemorrhage group and 2.57% in the control group of cerebral hemorrhage. With a significant difference between the two groups（P=0.000）. The prevalence rate of LAA in spouses of the LAA group was 4.62%, and the controlgroup was 2.31%, with no significant difference between the two groups. The prevalence rate of spouses in patients with cerebral hemorrhage was 2.31% and 1.54% in the control group. There was no statistical difference between the groups. The heritability of the first and second degree relatives of LAA was 44.94% and 18.81% respectively. The heritability of the first and second degree relatives of cerebral hemorrhage was 51.00% and 38.75% respectively. Conclusion Both LAA and cerebral hemorrhage have obvious familial aggregation, and genetic factors are one of the important causes of familial aggregation.

关 键 词：脑血管病 大动脉粥样硬化性脑梗死 危险因素 病例对照研究 遗传度 分离比 

分 类 号：R739.41[医药卫生—肿瘤]