肌萎缩侧索硬化症治疗的研究进展  

New Progress of the Treatment on Amyotrophic Lateral Sclerosis

作　　者：朱银伟 王国军[1] ZHU Yin-wei;WANG Guo-jun(Department of Neurology,Changshu Hospital Affiliated to Soochow University,the First People＇s Hospital of Changshu City,Changshu 215500,China.)

机构地区：[1]常熟市第一人民医院神经内科,常熟215500

出　　处：《中国临床神经科学》2018年第5期564-569,共6页Chinese Journal of Clinical Neurosciences

摘　　要：肌萎缩侧索硬化症是以大脑和脊髓运动神经元退行性改变为特征的进行性麻痹性疾病。目前,尚无有效治疗方法可以使肌萎缩侧索硬化症患者有实质性获益。对肌萎缩侧索硬化症患者干预的主要观点为尽早进行症状干预,包括营养支持、防止误吸、呼吸支持。随着遗传及药物的技术新进展,一些创新的治疗方法已进入临床前和临床研究。文中就肌萎缩侧索硬化症的药物治疗、非药物症状干预、新型治疗方法予以介绍。Amyotrophic lateral sclerosis（ALS） is a progressive, paralytic disorder characterized by degeneration of motor neurons in the brain and spinal cord. There is not yet any treatment that can make ALS patients have substantial benefits. The main point of ALS patient management is to do symptom intervention early, including nutritional support, prevention of mistaken aspiration, and respiratory support. With the new technology progress in genetics and pharmacology, some innovative treatment methods have entered into preclinical and clinical research. The drug treatment, the symptoms intervention, and the new treatment methods of ALS were reviewed.

关 键 词：肌萎缩侧索硬化症 治疗 临床研究 

分 类 号：R744.8[医药卫生—神经病学与精神病学]