丹红注射液联合前列地尔对缺血性脑梗死患者脑血管储备功能及神经功能缺损的影响  

Effect of danhong injection combined with alprostadil on cerebral vascular reserve and neurological impairment in patients with ischemic cerebral infarction

作　　者：张明[1] 李密 郑永平[1] 唐丽君[2] 隆世宇 ZHANG Ming;LI Mi;ZHENG Yong-ping;TANG Li-jun;LONG Shi-yu(Department of Neurology;Department of Anesthesiology,People＇s Hospital of Yilong County,Yilong 637600;Department of Neurology,the Fifth People＇s Hospital of Nanchong,Nanchong 637000,Sichuan,China)

机构地区：[1]仪陇县人民医院神经内科 [2]仪陇县人民医院手术麻醉科,四川仪陇637600 [3]南充市第五人民医院神经内科,四川南充637000

出　　处：《川北医学院学报》2018年第5期777-780,共4页Journal of North Sichuan Medical College

摘　　要：目的:探讨分析丹红注射液联合前列地尔对缺血性脑梗死患者脑血管储备功能及神经功能缺损的影响。方法:选取108例缺血性脑梗死患者作为研究对象,根据随机数字表分为对照组和观察组,每组54例。对照组患者采用前列地尔注射液治疗,观察组在前列地尔基础上给予丹红注射液联合治疗,分别比较两组患者临床治疗效果、治疗前后脑血管储备功能(CVR)、屏气指数(BHI)血液流变学相关指标水平以及不良反应发生情况,同时对两组患者治疗前后神经功能缺损评分进行对比。结果:治疗结束后,对照组有效率仅为35. 2%,观察组有效率达到61. 1%,差异具有统计学意义(P <0. 05);治疗后观察组CVR、BHI明显高于对照组,NIHSS评分显著低于对照组,差异具有统计学意义(P <0. 05);与对照组相比,治疗后观察组在血细胞比容、血浆黏度、纤维蛋白原均显著低于对照组,差异具有统计学意义(P <0. 05);对照组和观察组不良反应发生率分别为14. 8%,13. 0%,两组差异无统计学意义(P> 0. 05)。结论:对缺血性脑梗死患者联合应用丹红注射液和前列地尔进行治疗,有效改善脑血管储备功能和血液流变学状态,同时患者神经功能明显改善,治疗效果显著提高,不良反应发生率较低,值得在临床进一步应用。Objective： To investigate the effect of Danhong injection combined with alprostadil on cerebral vascular reserve and neurological deficits in patients with ischemic cerebral infarction. Methods： A total of 108 patients with ischemic cerebral infarction were selected as the research objects.According to the random number table,the patients were divided into control group and observation group,54 cases in each group.The control group was treated with alprostadil,and the observation group was treated with Danhong injection on the basis of alprostadil.The clinical effects,cerebrovascular reserve function （CVR）,breath holding index （BHI） level of hemorheology related indexes and adverse reactions occurred rate were compared,the neurological deficit scores between the two groups before and after treatment were compared. Results： After the treatment,the effective rate of the control group was only 35.2%,the effective rate of the observation group reached 61.1%,the difference was statistically significant （ P 〈0.05）.After treatment,the CVR and BHI of the observation group were significantly higher than those of the control group,while the NIHSS score was significantly lower than that of the control group （ P 〈0.05）.Compared with the control group,the observation group was significantly lower in hematocrit,plasma viscosity and fibrinogen after treatment than the control group,the differences were statistically significant （ P 〈0.05）.The incidence of adverse reactions in the control group and observation group were 14.8% and 13.0%,respectively,there was no significant difference between them （ P 〉0.05）. Conclusion： The combination of Danhong injection and alprostadil can significantly improve the treatment effect,the cerebral vascular reserve function,hemorheological status and neurological function,improve the effect of treatment significantly and decrease the incidence of adverse reactions,it is worth to further clinical application.

关 键 词：丹红注射液 前列地尔 缺血性脑梗死 脑血管储备功能 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]