线粒体肌酸激酶检测在中晚期结直肠癌治疗中的应用分析  

Application of mitochondrial creatine kinase detection in the treatment of advanced colorectal cancer

作　　者：陈兴秀[1] 赵兴丽[1] 郑东星[1] 谢红霞[1] 高建红[2] 刘毅 CHEN Xing-xiu;ZHAO Xing-li;ZHENG Dong-xing;Xie Hong-xia;GAO Jian-hong;LIU Yi(Dept.of Oncology,Binzhou People＇s Hospital,Binzhou 256600,China;Binzhou People＇s Hospital Central Laboratory,Binzhou 256600,China)

机构地区：[1]滨州市人民医院肿瘤二科,山东滨州256600 [2]滨州市人民医院中心实验室,山东滨州256600

出　　处：《泰山医学院学报》2018年第12期1334-1336,共3页Journal of Taishan Medical College

基　　金：滨州市科技发展计划;(课题编号:2015ZC0314)

摘　　要：目的对应用线粒体肌酸激酶检测方式对病情处于中晚期阶段的结直肠癌疾病患者接受放化疗的效果进行评价的临床价值进行研究。方法选择我院收治的接受放化疗的病情处于中晚期阶段的结直肠癌疾病患者153例,再抽取同期接受健康体检的健康人资料153例,分别将其定义为研究组和对照组。对对照组和研究组在放化疗前后的癌胚抗体水平和线粒体肌酸激酶水平进行测定,对比两组研究对象和研究组在放化疗前后的上述两项指标的测定结果与阳性率。结果研究组研究对象治疗前的癌胚抗体和线粒体肌酸激酶水平和阳性率明显高于对照组,组间数据比较差异显著(P <0. 05);研究组研究对象在治疗后癌胚抗体和线粒体肌酸激酶水平和阳性率明显低于治疗前,组内数据对应比较差异显著(P <0. 05)。结论病情处于中晚期阶段的结直肠癌疾病患者的线粒体肌酸激酶水平会呈现异常升高表现,通过放化疗技术对其进行治疗可以使这一指标水平明显降低,在病情诊断和治疗效果监测过程中,联合检测癌胚抗体水平可以有效提高检测阳性率,使监测的准确度更加理想。Objective ： To evaluate the clinical value of the application of mitochondrial creatine kinase in the evaluation of the effect of radiotherapy and chemotherapy for colorectal cancer patients in the advanced stage of the disease. Methods ： In our hospital 153 patients undergoing chemotherapy patients in advanced stage of colorectal cancer patients, then extract and underwent physical examination of healthy people in 153 cases, respectively, the which is defined as the study group and the control group. The control group and the study group before and after chemotherapy carcinoembryonic antibody level and nfitochondrial creatine kinase levels were measured, compared to two groups of research object and research group in two afore-mentioned index before and after chemotherapy and the test results of the positive rate. Results： Before treatment group study carcinoembryonic antibody and mitochondrial creatine kinase level and positive rate of was significantly higher than that of the control group, between group differences were significant （P 〈 0. 05） ; the research subjects in the treatment of carcinoembryonic antibody and nfitochondrial creatine kinase levels and positive rates significantly lower than the treatment before and group data corresponding to the difference significant （P 〈 0. 05 ）. Conclusion： Condition in middie and late stage of colorectal cancer patients of mitochondrial creatine kinase level will show an abnormal increase, through chemotherapy on the treatment can make the index level is significantly reduced, in disease diagnosis and monitoring the efficacy of treatment process, the combined detection of carcinoembryonic antibody level can effectively improve the positive detection rate, so as to make the monitoring accuracy is more ideal.

关 键 词：中晚期阶段 结直肠癌 线粒体肌酸激酶 癌胚抗体 放化疗 

分 类 号：R735[医药卫生—肿瘤]