多巴胺与癫痫关系的研究  

Research on the relationship between dopamine and epilepsy

作　　者：高敏[1] 张敬军[1] Gao Min;Zhang Jingjun(Department of Neurology,Mount Taishan Medical School Affiliated Hospital,Tai＇an 271000,China)

机构地区：[1]泰山医学院附属医院神经内科,山东泰安271000

出　　处：《中华脑科疾病与康复杂志（电子版）》2017年第2期83-86,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：山东省医药卫生科技发展计划（2014WS0196）;山东省高等学校科技计划（J15LL07）;首都医科大学重点实验室开放研究课题（2016-1）

摘　　要：多巴胺是中枢神经系统单胺类神经递质之一, 参与多种神经活动的调节.癫痫是常见病, 多发病, 发病机制未明, 是国内外研究的难点之一.研究发现多巴胺与癫痫关系密切相关, 是国内外研究的热点.本文通过综述多巴胺的结构、 分布、 生物学功能、 调控机制及其与癫痫的关系, 为癫痫的靶向治疗提供新的理论依据, 对提高癫痫的防治水平具有重要价值.As one of monoamine neurotransmitters in the central nervous system, dopamine participates in the regulation of many kinds of neural activities. Epilepsy is a common disease, frequently occurring disease and the pathogenesis is unknown, which is one of the difficult points in the domestic and foreign research. Studies have found that dopamine is closely related to the occurrence of epilepsy,which is a hot research topic at home and abroad. The structure, distribution, biological function and regulation meehanism of dopamine and its relationship with epilepsy were reviewed in this paper,which provide a new theoretical basis for the targeted therapy of epilepsy and improve the level of prevention and treatment of epilepsy is of great value.

关 键 词：癫痫 多巴胺 多巴胺受体 

分 类 号：R742.5[医药卫生—神经病学与精神病学]