牙龈卟啉单胞菌菌毛致病机制的研究进展  

Research progress in the pathogenic mechanisms of Porphyromonas gingivalis fimbriae

作　　者：杜留熠 孙晓琳[1] 于维先 任静宜 顾芯铭[1] 周延民[1] Du Liuyi;Sun Xiaolin;Yu Weixian;Ren Jingyi;Gu Xinming;Zhou Yanmin(Department of Implant Center,School of Stomatology,Jilin University,Changchun 130021,China;Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,School of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医学院种植科,长春130021 [2]吉林省牙发育及颌骨重塑与再生省重点实验室

出　　处：《中华口腔医学杂志》2018年第10期703-707,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金（81570983）;吉林省科技厅国际合作处项目（20180414030GH）

摘　　要：FimA蛋白是牙龈卟啉单胞菌的重要毒力因子,在牙龈卟啉单胞菌黏附和入侵宿主细胞,促进牙菌斑生物膜形成以及引起宿主免疫炎症反应的过程中发挥重要作用,与牙周病和心血管疾病的发生和发展密切相关.根据编码FimA蛋白的fimA基因核苷酸序列的不同可将牙龈卟啉单胞菌分为Ⅰ、Ⅰb、Ⅱ、Ⅲ、Ⅳ和Ⅴ型共6种基因型.FimA的表达受fimA基因的调控,不同fimA基因型菌毛的致病作用有一定差异.本文就牙龈卟啉单胞菌菌毛相关致病机制的研究进展进行综述.FimA has been characterized as an important virulence factor for Porphyromonas gingivalis （Pg）.These structures play a major role in the mechanisms of adhesion and invasion of Pg to host cells,and can induce cellular activation and cytokines release.FimA can also promote biofilm formation and induce immuno-inflammatory response of host cells.Many studies have characterized FimA to be associated with periodontitis and cardiovascular disease.Pg strains are classified into six types based on divergent nucleotide sequences of the fimA gene （types Ⅰ 、Ⅰb、Ⅱ 、Ⅲ 、Ⅳ and Ⅴ）.The expression of fimbriae is regulated by the fimA gene,which may be the key factor that leads to virulence diversities of Pg,At present,the research on the pathogenesis of FimA mainly focuses on periodontitis and atherosclerosis,which is of great significance for the prevention and treatment of diseases.This paper reviewed the pathogenic effect of FimA in the development of above mentioned two diseases and its application in the prevention.

关 键 词：紫单胞菌 龈 纤毛 细菌 牙周炎 动脉粥样硬化 fimA基因 

分 类 号：R780.2[医药卫生—口腔医学]