富血小板纤维蛋白治疗Ⅱ度根分叉病变的效果评价  

Effect of platelet rich fibrin combining with Bio-oss to treat furcation involvement

作　　者：沈敏华[1] 黄远亮[1] 厉祯[1] 张迎娣[1] 何燕萍 王磊[1] SHEN Min-hua;HUANG Yuan-liang;LI Zhen;ZHANG Ying-di;HE Yan-ping;WANG Lei(Department Of Stomatology,Shanghai East Hospital Affiliated to Tongii University.Shanghai 200120,China)

机构地区：[1]同济大学附属东方医院口腔科,上海200120

出　　处：《上海口腔医学》2018年第5期508-512,共5页Shanghai Journal of Stomatology

基　　金：浦东新区卫生和计划生育委员会青年科技项目(PW2015B-7);浦东新区科技发展基金创新课题项目(PKJ2013-Y15)

摘　　要：目的:观察富血小板纤维蛋白(platelet rich fibrin, PRF)联合Bio-oss治疗Ⅱ度根分叉病变的临床效果。方法:选取临床Ⅱ度根分叉病变的下颌第一磨牙患者30例,经过牙周基础治疗后,随机分为实验组和对照组(各15例)。实验组采用引导牙周组织再生术,术中PRF联合Bio-oss植入骨缺损区并覆盖PRF膜;对照组仅采用单纯牙周翻瓣术。术后6个月回访,通过临床牙周指数检查及锥形束CT(CBCT)检查评价临床疗效。采用SPSS2.0软件包进行统计学分析。结果:2组患者术后牙周探诊深度(probing depth,PD)、临床附着丧失(clinical attachment loss,CAL)、根分叉水平探入深度(horizontal probing depth,HPD)均较术前显著改善(P<0.05),且2组间差异具有统计学意义(P<0.05);实验组术后根分叉区骨增量与对照组之间有显著差异(P<0.05)。结论:PRF联合Bio-oss明显促进牙周Ⅱ度根分叉病变区成骨,改善牙周状况,临床效果显著。PURPOSE： To evaluate the effect of platelet rich fibrin （PRF） combining with Bio-oss in treating Class Ⅱ furcation involvement. METHODS： Thirty patients who had Class Ⅱ furcation involvement in the mandibular first molar were included. They were all free of systemic disease. After initial periodontal therapy, they were randomly divided into 2 groups. In the experimental group, PRF combining with Bio-oss were placed in the areas with furcation defect and covered with PRF. In the control group, only flap surgery was performed. All patients were followed up for 6 months after operation. The efficacy was evaluated with clinical parameters and cone-beam computed tomography （CBCT）. The data were analyzed with SPSS 2.0 software package. RESULTS： Periodontal indexes including probing depth （PD）, clinical attachment loss （CAL）, horizontal probing depth （HPD） significantly decreased in both groups after operation （P〈0.05）; alveolar bone significantly increased in the experimental group （P〈0.05）. CONCLUSIONS： The clinical effect of PRF combined with Bio-oss on Class II furcation involvement are remarkable.

关 键 词：富血小板纤维蛋白 Ⅱ度根分叉病变 BIO-OSS骨粉 锥形束CT 

分 类 号：R781.4[医药卫生—口腔医学]