近视眼患者波前像差和对比敏感度相关分析  

Comparison of contrast sensitivity and wavefront aberrations with myopic

作　　者：高欢欢 杜之渝[1] 晏丕松 张玙 李涛[1] Gao Huanhuan;Du Zhiyu;Yan Pisong;Zhang Yu;Li Tao(Department of Ophthalmology,The Second Affilited Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院眼,400010 [2]重庆明达眼科

出　　处：《中华眼科杂志》2018年第10期748-755,共8页Chinese Journal of Ophthalmology

摘　　要：目的分析近视眼人群中的视力、波前像差和对比敏感度的相互关系。方法回顾性系列病例研究。选择2013年4月至2015年8月在重庆医科大学附属第二医院及重庆明达眼科医院就诊的近视眼患者112例（209只眼），其中男性54例（102只眼），女性58例（107只眼）；年龄（27．5±9．20）岁。所有患者根据最佳矫正视力（BCVA）分为BCVA1．0组和BCVA1．2组，检测不同光照条件下的对比敏感度函数曲线下面积（AULCSF）及瞳孔直径分别为4和6mm时的全眼和角膜像差，并将BCVA1．2组的患者根据对比敏感度和像差的高低进一步分组，观察两者之间的关系。组问数据的的比较均采用独立样本t检验分析；多元逐步回归方法和多元线性回归方法了解不同光照条件下各空间频率的对比敏感度以及AULCSF与全眼各像差的关系。结果BCVA1．2组患者明光、暗光条件下AULCSF分别为1．32±0．10、1．30±0．12，均高于BCVA1．0组（t=一3．58，一2．48；P〈0．05），暗光眩光状态下的AUl．CSF两组比较差异无统计学意义；瞳孔直径为4和6mm时，BCVA1．0组和BCVA1．2组的全眼像差组中除z～，差异有统计学意义（t=2．09，P=O．04；t=--2．05，P=O．04），其余全眼像差和角膜各像差问差异无统计学意义。明光、暗光、暗光眩光3种光照条件下，低对比敏感度组球差分别为（0．019±0．010）、（0．136±0．117）、（0．006±0．003）μm，高于高对比敏感度组的球差（0．013±0．006）、（0．083±0．054）、（0．004±0．002）μm，差异有统计学意义（t=1．15，2．65，2．44；P〈0．05）。暗光、暗光眩光两种光照条件下球差较大组AULCSF分别为1．281±0．126、1．216±0．154，低于球差较小组的1．323±0．106、1．262±0．113，差异有统计学意义（t=2．14，1．98；P〈0．05）。各光照条件各空间频率中，总像差、球差对对比敏感度呈负性�Objective Correlation analysis of visual acuity, wavefl＇ont aberrations and contrast sensitivity in myopia. Methods Retrospective study. One hundred and twelve patients with myopia（209 eyes） from April 2013 to August 2015 were enrolled in our study. All subjects were divided into various groups to investigate the relationship between wavefront aberrations and contrast sensitivity in myopic eyes. The correlations between ocular aberrations and contrast sensitivity（4 spatial frequency）in myopia eyes were analyzed using multivariate stepwise regression. Results The AULCSF in the BCVA 1.2 were 1.32_±0.10, 1.30_±0.12 respectively in tile light and dark conditions,, which were higher than those in the BCVA 1.0 （t=-3.58 and -2.48, P〈O.05）. There was no significant difference between AULCSF in dark glare condition. At 4ram and 6mm pupil diameters, The difference in Z-~3 of ocular higher-order aberrations between the BCVA 1.0 and the BCVA 1.2 was statistically significant （t=2.09, P=O.04; t=-2.05, P=0.04）. Differences between the other ocular higher-order aberrations and corneal aberrations were not statistically signit]cant. The spherical aben＇ations of the low contrast sensitivity group were （0.019±0.010）, （0.136±0.117） and（0.006±0.003）μm separately under the condition of bright light, dark light and dark glare light, which were higher than other groups （0.013±0.006）, （0.083±0.054）, （0.004±0.002）μm （t=l.lO, 2.65, 2.44, P〈0.05）. The values of AULCSF for the larger spherical aberrations under clark light and dark glare light conditions were 1.281±0.126 and 1.216±0.154 respectively which were lower than the AULCSF 1.281±0.126, 1.216± 0.154 of the another spherical aberrations group （t=2.14, 1.98, P〈0.05）. It was found that the SAll RMS and spherical aberrations under different frequencies and illuminating conditions were negatively correlated with CS.Vertieal coma was positively correlated with CS. Conclusions Better BCVA may achieve better visual qual

关 键 词：近视 角膜波前像差 对比敏感度 

分 类 号：R778.11[医药卫生—眼科]