阿替普酶溶栓治疗急性脑梗死的临床效果及对神经功能的影响  

Clinical Effect of Ateplase Thrombolytic Therapy on Acute Cerebral Infarction and Its Effect on Neurological Function

作　　者：宋田佳[1] SONG Tian-jia(Department of Emergency Medicine,Linfen People＇s Hospital,Linfen,Shanxi Province,041000 China)

机构地区：[1]山西省临汾市人民医院急诊医学科,山西临汾041000

出　　处：《系统医学》2018年第19期37-38,41,共3页Systems Medicine

摘　　要：目的探讨阿替普酶溶栓治疗急性脑梗死的临床效果及对神经功能的影响。方法 2016年7月—2017年12月将108例急性脑梗死患者按随机数表法分为两组,各54例。对照组给予常规方案治疗,研究组给予阿替普酶溶栓治疗,比较两组临床疗效、神经功能、日常生活能力以及不良反应发生情况。结果研究组治疗总有效率为85.19%(46/54),明显高于对照组66.67%(36/54),差异有统计学意义(χ~2=5.066,P=0.024);治疗后1个月,研究组NIHSS评分明显低于治疗前与对照组,差异有统计学意义(t=16.709、6.044,P=0.000);治疗后1个月,研究组ADL评分明显高于治疗前与对照组,差异有统计学意义(t=9.511、4.020,P=0.000);研究组不良反应发生率差异无统计学意义(χ~2=0.911,P=0.340)。结论对急性脑梗死患者采用阿替普酶溶栓治疗,可有效改善患者神经功能,促进日常生活能力恢复,安全性较高,值得推广。Objective To investigate the clinical effects of aheplase in the treatment of acute cerebral infarction and its effect on neurological function. Methods 108 patients with acute cerebral infarction from July 2016 to December 2017 were divided into two groups according to the random number table method, 54 cases each. The control group was treated with conventional regimen, and the study group was treated with aheplase thrombolytic therapy. The clinical efficacy, neurological function, daily living ability and adverse reactions were compared between the two groups. Results The total effective rate of the study group was 85.19%（46/54）, which was significantly higher than that of the control group 66.67% （36/54）. The difference was statistically significant （x^2=5.066,P=0.024）. One month after treatment, the NIHSS score of the study group was significantly lower than that of the control group. The difference was statistically significant （t=16.709,6.044,P=0.000）. One month after treatment, the ADL score of the study group was significantly higher than that before treatment and the control group. The difference was statistically significant （t=9.511,4.020,P=0.000）; there was no significant difference in the incidence of adverse reactions in the study group （x^2=0.91140=0.340）. Conclusion The use of aheplase thrombolytic therapy in patients with acute cerebral infarction can effectively improve the neurological function of patients, promote the recovery of daily living ability, and has high safety and is worthy of promotion.

关 键 词：阿替普酶溶栓 急性脑梗死 神经功能 不良反应 日常生活能力 

分 类 号：R743[医药卫生—神经病学与精神病学]