炎症性肠病发病机制的研究进展  

Advances in Research on Pathogenesis of Inflammatory Bowel Disease

作　　者：王岭玉 吴瑾[1] WANG Lingyu;WU Jin(Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicin;Shanghai Institute for Pediatric Researc;Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition,Shanghai,20009)

机构地区：[1]上海交通大学医学院附属新华医院上海市儿科医学研究所上海市小儿消化与营养重点实验室,200092

出　　处：《胃肠病学》2018年第10期630-633,共4页Chinese Journal of Gastroenterology

基　　金：上海市自然科学基金(16ZR1428500)

摘　　要：炎症性肠病(IBD)是一组慢性非特异性肠道炎性疾病,主要包括溃疡性结肠炎(UC)和克罗恩病(CD),其病因和发病机制尚未明确。目前观点认为IBD是环境因素、肠道菌群、遗传易感性以及免疫因素等多种因素间复杂作用的结果。本文就IBD发病机制的研究进展作一综述。Inflammatory bowel disease （IBD）, including ulcerative colitis （UC） and Crohn’s disease （CD）, is a chronic non-specific intestinal inflammatory disease and its pathogenesis has not yet been fully clarified. The current view is that IBD is the result of complex interactions among various factors, such as environment, intestinal flora, hereditary susceptibility and immune. This article reviewed the advances in research on pathogenesis of IBD.

关 键 词：炎症性肠病 发病机制 环境 肠道菌群 遗传 免疫 

分 类 号：R574[医药卫生—消化系统]