上皮钠通道与炎症性肠病关系的研究进展  

Advances in Study on Relationship Between Epithelial Sodium Channel and Inflammatory Bowel Disease

作　　者：王丹丹[1] 杨贝贝 高闯 杜晓博 耿丽 王许平 冯百岁[1] WANG Dandan;YANG Beibei;GAO Chuang;DU Xiaobo;GENG Li;WANG Xuping;FENG Baisui(Department of Gastroenterology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,450014)

机构地区：[1]郑州大学第二附属医院消化内科,450014

出　　处：《胃肠病学》2018年第10期634-637,共4页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金资助项目(81070288;81270452);河南省卫生计生科技创新型人才特聘学科带头人;河南省自然科学基金项目(162300410268);河南省医学科技攻关计划项目(201502015)

摘　　要：炎症性肠病(IBD)是一种自身免疫性疾病,可导致腹泻、腹痛、体质量丢失等症状。腹泻的发病机制尚不清楚,但越来越多的证据表明上皮钠通道(ENaC)与腹泻有关。ENaC对控制钠稳态、细胞外液总量、血压等方面至关重要。本文就ENaC与IBD的关系作一综述。Inflammatory bowel disease （IBD） is an autoimmune disease leading to diarrhea, abdominal pain, and weight loss. The pathogenesis of diarrhea remains unclear, however, increasing evidence has shown that the epithelial sodium channel （ENaC） is associated with diarrhea. ENaC is crucial in the control of sodium homeostasis, extracellular fluid volume, blood pressure. This article reviewed advances in study on relationship between ENaC and IBD.

关 键 词：上皮钠通道 炎症性肠病 细胞外信号调节激酶类 肿瘤坏死因子Α 

分 类 号：R574[医药卫生—消化系统]