汉族和维吾尔族宫颈癌患者外周血CD4^+CD25^+调节性T细胞与TGF-β1及IL-10的表达及意义  

Expression and significance of TGF-β1,IL-10 and CD4^+CD25^+ regulatory T cells of peripheral blood in cervical cancer patients of the Hans and Uygurs

作　　者：陈志刚[1] 阿曼古丽[2] 陈志芳[3] 李宏[1] Chen Zhigang;A Manguli;Chen Zhifang;Li Hong(The First Affiliated Hospital Medical Laboratory of Shihezi University Medical School,Shihezi,Xinjiang,832008,China;Department of Gynaecology,The First Affiliated Hospital of Shihezi University Medical School,Shihezi,Xinjiang,832008,China;Department of Gynaecology,the First Affiliated Hospital,Xinjiang Medical University,Wulumuqi,Xinjiang,830054,China)

机构地区：[1]石河子大学医学院第一附属医院医学实验室,新疆石河子832008 [2]石河子大学医学院第一附属医院妇科,新疆石河子832008 [3]新疆医科大学第一附属医院妇科,新疆乌鲁木齐830054

出　　处：《当代医学》2018年第31期62-64,共3页Contemporary Medicine

基　　金：国家自然科学基金(81660475)

摘　　要：目的探讨汉族、维吾尔族宫颈癌患者外周血中CD4^+CD25^+调节性T细胞(Treg)及转化生长因子-转化(TGF-β1)、白细胞介素-10(IL-10)的表达及意义。方法采用流式细胞术对维吾尔族、汉族宫颈癌患者外周血CD4^+CD25^+Treg细胞进行检测,同时采用ELISA法检测血清中细胞因子TGF-β1、IL-10表达水平。结果同健康对照组比较,两民族宫颈癌患者外周血Treg细胞和TGF-β1、IL-10表达明显升高,差异具有统计学意义(P<0.05)。维吾尔宫颈癌患者Treg细胞表达高于汉族宫颈癌患者,差异具有统计学意义(P<0.05)。宫颈癌患者外周血Treg细胞和TGF-β1、IL-10表达水平具有明显相关性(P<0.05)。结论宫颈癌患者外周血Treg细胞和TGF-β1、IL-10表达明显升高,可能在肿瘤免疫逃逸和发生、发展中起到重要作用。Objective To explore the expression and significance of TGF-β1,IL-10 and CD4＋CD25＋ regulatory T cells of peripheral blood incervical cancer patients of the Hans and Uygurs. Methods Flow cytometry was used to detect the CD4＋CD25＋Treg cells in uygurs and hans patientswith cervical cancer, and the serum cytokine TGF-β1 and IL-10 expression levels were detected by ELISA. Results Compared with the healthy controlgroup, the expression of Treg cells and TGF-β1 and IL-10 in the peripheral blood of cervical cancer patients of two nations were significantly increased,and the difference was statistically significant （P〈0.05）. There was a significant correlation between peripheral blood Treg cells and TGF-β1 and IL-10 expression levels in patients with cervical cancer （P〈0.05）. Conclusion The expression of Treg cells and TGF-β1 and IL-10 in peripheralblood of cervical cancer patients may play an important role in tumor immune escape and development.

关 键 词：汉族 维吾尔族 宫颈癌 调节性T细胞 转化生长因子-Β1 白细胞介素-10 

分 类 号：R737.33[医药卫生—肿瘤]