卵巢癌患者血清中hk10、DJ-1含量对肿瘤恶性生物学的评估价值研究  

Value of serum hk10 and DJ-1 levels in evaluating ovarian cancer malignancy

作　　者：周海清 孟庆荣 张琳琳[2] 王莹 ZHOU Hai-qing;MENG Qing-rong;ZHANG Lin-lin;WANG Ying(Department of Gynecology,Lanling County People＇s Hospital of Linyi Shandong Province,Linyi,Shandong 277700,China)

机构地区：[1]山东省临沂市兰陵县人民医院妇科,山东临沂277700 [2]山东省临沂市人民医院妇科,山东临沂276000 [3]山东省临沂市妇女儿童医院妇科,山东临沂276000

出　　处：《海南医学院学报》2018年第20期1825-1828,共4页Journal of Hainan Medical University

基　　金：山东省临沂市科技局(201717049)~~

摘　　要：目的:探讨卵巢癌患者血清中hk10、DJ-1含量对肿瘤恶性生物学的评估价值。方法:选取在本院接受手术治疗的卵巢癌患者80例作为卵巢癌组、卵巢囊肿患者67例作为卵巢囊肿组。对比两组术前血清中hk10、DJ-1含量及术中病灶组织卵巢癌相关增殖基因、侵袭基因表达量的差异。采用相关性分析评估卵巢癌患者血清中hk10、DJ-1含量与肿瘤恶性程度的内在联系。结果:卵巢癌组血清中hk10、DJ-1的含量高于卵巢囊肿组;病灶组织中增殖基因Clusterin、FUNDC1、AKT、TNFAIP8、HBXIP mRNA的表达量均高于卵巢囊肿组;病灶组织中侵袭基因Beclin1、BRMS1、SIRT2mRNA的表达量低于卵巢囊肿组,EFEMP1mRNA的表达量高于卵巢囊肿组(P<0.05)。Pearson检验发现,卵巢癌血清中hk10、DJ-1含量与增殖基因、侵袭基因的表达量直接相关。结论:卵巢癌患者血清中高表达hk10、DJ-1,其具体含量与癌细胞的增殖、侵袭活力直接相关。Objective： To discuss the value of serum hk10 and DJ-1 levels in evaluating the malignancy of ovarian cancer. Methods： A total of 80 patients with ovarian cancer who underwent surgical treatment in Lanling County People＇s Hospital between August 2015 and February 2018 were selected as ovarian cancer group, and 67 patients with ovarian cyst were selected as ovarian cyst group. The differences in the levels of hk10 and DJ-1 in preoperative serum as well as the expression of ovarian cancer-related proliferation genes and invasion genes in intraoperative lesion tissue were compared between the two groups. Correlation analysis was used to assess the inner correlation between serum hk10 and DJ-1 levels and tumor malignancy in patients with ovarian cancer. Results： Serum hk10 and DJ-1 levels of ovarian cancer group were higher than those of ovarian cyst group; proliferation genes Clusterin, FUNDC1, AKT, TNFAIP8 and HBXIP mRNA expression in lesion tissues of ovarian cancer group were higher than those of ovarian cyst group; invasion genes Beclin1, BRMS1 and SIRT2 mRNA expression in lesion tissues of ovarian cancer group were lower than those of ovarian cyst group, whereas EFEMP1 mRNA expression was higher than that of ovarian cyst group （ P 〈0.05）. The Pearson test showed that serum hk10 and DJ-1 levels in ovarian cancer were directly correlated with the expression of proliferation genes and invasion genes. Conclusion： Hk10 and DJ-1 are highly expressed in serum of patients with ovarian cancer, and their levels are directly correlated with the proliferation and invasion activity of breast cancer cells.

关 键 词：卵巢癌 hk10 DJ-1 增殖基因 侵袭基因 

分 类 号：R737.31[医药卫生—肿瘤]