Survivin、bFGF、VEGF在宫颈癌组织中的表达及其与临床病理特征的关系研究  

Expressions of Survivin,bFGF and VEGF in Cervical Cancer and their Relationship with Clinicopathological Features

作　　者：周庆红 洛若愚[1] 周晓红 王君 陈芳 ZHOU Qing-hong;LUO Ruo-yu;ZHOU Xiao-hong;WANG Jun;CHEN Fang(Department of Gynecology and Obstetrics,Renmin Hospital of Wuhan University,Wuhan,Hubei,430060,China;Department of Gynecology and Obstetrics,Xiangyang NO.1 People＇s Hospital,Xiangyang,Hubei,441000,China)

机构地区：[1]武汉大学人民医院妇产科,湖北武汉430060 [2]襄阳市第一人民医院妇产科,湖北襄阳441000

出　　处：《现代生物医学进展》2018年第18期3467-3470,3562,共5页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(2013CFC0328)

摘　　要：目的:研究存活素(Survivin)、碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)在宫颈癌组织中的表达及其与临床病理特征的关系。方法:选择2015年1月-2017年12月期间武汉大学人民医院收治的宫颈癌患者95例为宫颈癌组,宫颈上皮内瘤变患者70例为宫颈上皮内瘤变组,取同期在我院进行治疗的宫颈炎患者50例纳入对照组。采集三组患者的宫颈组织标本,采用免疫组化SP法对各组织标本中的Survivin、bFGF、VEGF的阳性率、表达水平进行检测,并分析Survivin、bFGF、VEGF与宫颈癌临床病理特征的关系以及各指标表达水平的相关性。结果:宫颈癌组、宫颈上皮内瘤变组的Survivin、bFGF、VEGF的阳性表达率、表达水平均高于对照组,且宫颈癌组高于宫颈上皮内瘤变组(P<0.05)。Survivin、bFGF、VEGF的表达与宫颈癌患者的年龄、病理类型、分化程度无关(P>0.05),而与宫颈癌肿瘤的分期、淋巴结转移有关(P<0.05)。Spearman相关性分析显示,Survivin、bFGF、VEGF三者间的表达水平两两呈正相关(P<0.05)。结论:Survivin、bFGF、VEGF的表达水平与宫颈癌的发生、发展有密切关联,并且三种指标间呈明显的正相关性,可能对于宫颈癌肿瘤组织的浸润、转移、分期发挥协同作用。Objective：To investigate the expressions of survivin（Survivin）,basic fibroblast growth factor（bFGF） and vascular endothelial growth factor（VEGF） in cervical cancer and their relationship with clinicopathological features.Methods：A total of 95 cases of cervical cancer were selected as cervical cancer group;70 cases of cervical intraepithelial neoplasia,as cervical intraepithelial neoplasia group and 50 cases of cervicitis,as control group,who were treated in Renmin Hospital of Wuhan University from January 2015 to December 2017.The cervical tissue specimens from the three groups were collected;the positive rate and expression level of Survivin,b FGF and VEGF were detected by immunohistochemical SP method.The relationship between Survivin,bFGF,VEGF and the clinicopathological features of cervical cancer and the correlation of the expression level of each index were analyzed.Results：The positive expression rate and expression level of Survivin,bFGF and VEGF of cervical cancer group and cervical intraepithelial neoplasia group were higher than those of control group,and the cervical cancer group was higher than that of the cervical intraepithelial neoplasia group（P〈0.05）.The expression of Survivin,bFGF and VEGF was not related to age,pathological type and degree of differentiation in the patients with cervical cancer（P〉0.05）,and was related to the staging and lymph node metastasis of cervical cancer（P〈0.05）.Spearman correlation analysis showed that the expression of Survivin,bFGF and VEGF was positively correlated to each other（P〈0.05）.Conclusion：The expression level of Survivin,bFGF and VEGF is closely related to the occurrence and development of cervical cancer,and there is a significant positive correlation among the three indicators,which may play a synergistic role in the invasion,metastasis and staging of cervical cancer tissue.

关 键 词：宫颈癌 存活素 碱性成纤维细胞生长因子 血管内皮生长因子 病理特征 

分 类 号：R737.33[医药卫生—肿瘤]