HGF和EZH2在宫颈癌组织中的表达及其与临床病理特征的关系  

Expression of HGF and EZH2 in Cervical Cancer and Its Relationship with Clinicopathological Characteristics

作　　者：周琦 李霞 田燕 张晓玉 陶玲 ZHOU Qi;LI Xia;TIAN Yah;ZHANG Xiao-yu;TAO Ling(Fourth Department of Gynecological Surgery,The Third Clinical Medical College of Xinjiang Medical University/Cancer Hospital Affiliated to Xinjiang Medical University,Urumqi,Xinjiang,830011,China)

机构地区：[1]新疆医科大学第三临床医学院/新疆医科大学附属肿瘤医院妇外四科,新疆乌鲁木齐830011

出　　处：《现代生物医学进展》2018年第18期3490-3493,共4页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2015211C130)

摘　　要：目的:探讨肝细胞生长因子(HGF)、果蝇zeste基因增强子2(EZH2)在宫颈癌组织中的表达及其与临床病理特征的关系。方法:选取2016年10月到2018年1月期间在新疆医科大学附属肿瘤医院接受治疗的宫颈癌患者50例,收集其手术切除的病理组织作为宫颈癌组的检测标本,另选取同期在我院收治的子宫肌瘤患者,收集其行全子宫切除术时切除的宫颈组织,其中上皮内瘤样病变(CIN)组织和正常宫颈组织各50例,CIN组织作为CIN组的检测标本,正常宫颈组织作为对照组的检测标本。比较宫颈癌组、CIN组和对照组标本中HGF和EZH2的阳性表达情况。分析HGF和EZH2的表达与宫颈癌患者临床病理特征的关系,分析宫颈癌组织中HGF、EZH2表达的相关性。结果:各组标本中的HGF和EZH2的阳性表达率整体比较差异均有统计学意义(P<0.05),宫颈癌组、CIN组的HGF和EZH2的阳性表达率均明显高于对照组,且宫颈癌组EZH2的阳性表达率高于CIN组(P<0.05)。宫颈癌组织中HGF和EZH2的表达与年龄、肿瘤类型、肿瘤大小无关(P>0.05),临床分期II期、有淋巴结转移、病理分级G3的宫颈癌组织中HGF和EZH2的阳性表达率高于临床分期I期、无淋巴结转移、病理分级G1+G2的宫颈癌组织(P<0.05)。经Spearman相关分析显示,宫颈癌组织中HGF与EZH2表达呈正相关(P<0.05)。结论:HGF和EZH2在宫颈癌组织中呈高表达,且其表达水平与临床分期、淋巴结转移、病理分级有关。Objective：To investigate the expression of hepatocyte growth factor（HGF） and enhancer of zeste homolog 2（EZH2）in cervical cancer and its relationship with the clinicopathological features.Methods：50 cases of cervical cancer who were treated in Cancer Hospital Affiliated to Xinjiang Medical University from October 2016 to January 2018 were selected,the pathological tissue of surgical resection was collected as the specimen of cervical cancer group,another uterine fibroids patients in our hospital during the same period were selected,the cervical tissues removed during hysterectomy were collected,there were 50 cases of intraepithelial neoplasia（CIN） or normal cervical tissue,CIN tissue as a test specimen of CIN group,normal cervical tissue as a test specimen of the control group.The positive expression of HGF and EZH2 in cervical cancer group,CIN group and control group were compared,the relationship between the expression of HGF and EZH2 and clinicopathological characteristics of cervical cancer patients were analyzed,the correlation between the expression of HGF and EZH2 in cervical cancer tissues was analyzed.Results：The positive expressions of HGF and EZH2 in all the groups were significantly different（P〈0.05）.The positive expression of HGF and EZH2 in the cervical cancer group and CIN group were significantly higher than that in the control group,the positive expression of EZH2 in the cervical cancer group was significantly higher than that of the CIN group（P〈0.05）.The expression of HGF and EZH2 in cervical cancer was not related to age,tumor type and size of tumor（P〈0.05）.The positive expression rate of HGF and EZH2 in cervical cancer tissues of clinical stage II stage,lymph node metastasis and pathological grade G3 was higher than that of I stage,no lymph node metastasis and pathological grading G1＋G2 in cervical cancer tissues（P〈0.05）.Spearman correlation analysis showed that there was a positive correlation between HGF and EZH2 expression in cervical cancer tissu

关 键 词：宫颈癌 肝细胞生长因子 果蝇zeste基因增强子2 表达 临床病理特征 关系 

分 类 号：R737.33[医药卫生—肿瘤]