半乳糖凝集素-3与程序性死亡受体-1在宫颈鳞癌组织中的表达及其临床意义  

Expression and Clinical Significance of Galectin-3 and Programmed Death Receptor-1 in Cervical Squamous Cell Carcinoma

作　　者：李婷 朱建福 毛瑛玉 林茂华 林妙春 沈丽蕊 LI Ting;ZHU Jian-fu;MAO Ying-yu;LIN Mao-hua;LIN Miao-chun;SHEN Li-rui(Department ofPathology,Mindong Hospital Affiliated to Fujian Medical University,Ningde,Fujian,355000,China;Department of Orthopedics,Mindong Hospital Affiliated to Fujian Medical University,Ningde,Fujian,355000,China;Central Laboratory,Mindong Hospital Affiliated to Fujian Medical University,Ningde,Fujian,355000,China)

机构地区：[1]福建医科大学附属闽东医院病理科,福建宁德355000 [2]福建医科大学附属闽东医院骨科,福建宁德355000 [3]福建医科大学附属闽东医院中心实验室,福建宁德355000

出　　处：《现代生物医学进展》2018年第18期3529-3532,共4页Progress in Modern Biomedicine

基　　金：福建省自然科学基金项目(2015J01572);福建省青年科研基金项目(2013-1-48)

摘　　要：目的:探讨半乳糖凝集素-3(Gal-3)和程序性死亡受体-1(PD-1)在宫颈鳞癌组织中的表达及其临床意义。方法:选择2016年1月-2017年12月期间我院收治的宫颈鳞癌患者80例纳入观察组,宫颈上皮内瘤变(CIN)患者60例纳入CIN组,取同期在我院进行治疗的宫颈炎患者50例纳入对照组。采集三组患者的宫颈组织标本,采用免疫组化SP法对各组织标本中的Gal-3、PD-1的阳性率、表达水平进行检测,并分析Gal-3、PD-1与宫颈鳞癌临床病理特征的关系以及各指标表达水平的相关性。结果:观察组、CIN组的Gal-3、PD-1的阳性表达率、表达水平均高于对照组,且观察组高于CIN组(P<0.05)。Gal-3、PD-1的表达与宫颈鳞癌患者的年龄、病灶大小、分化程度无关(P>0.05),而与宫颈鳞癌肿瘤的分期、淋巴结转移有关(P<0.05)。经Spearman相关性分析显示,宫颈鳞癌组织中Gal-3与PD-1间表达水平呈正相关性(r=0.496,P=0.000)。结论:Gal-3、PD-1的表达水平与宫颈鳞癌的发生、发展有密切关联,并且两种指标间呈明显正相关。Objective：To investigate the expression and clinical significance of galectin-3（Gal-3） and programmed death receptor-1（PD-1） in squamous cell carcinoma of the cervix.Methods：80 patients with cervical squamous cell carcinoma who were admitted to our hospital from January 2016 to December 2017 were included in the observation group,60 patients with cervical intraepithelial neoplasia（CIN） were included in the CIN group.50 patients with cervicitis who were treated in our hospital during the same period were included in the control group.The cervical tissue specimens from three groups were collected,the positive rate and expression level of Gal-3 and PD-1 in tissue samples were detected by immunohistochemical SP method,the relationship between Gal-3 and PD-1 and the clinicopathological characteristics of cervical squamous cell carcinoma and the correlation between the expression levels of various indicators were analyzed.Results：The positive expression rate and expression level of Gal-3 and PD-1 in the observation group and CIN group were all higher than those in the control group,and the observation group was higher than that in the CIN group（P〈0.05）.The expression of Gal-3 and PD-1 were not related to the age,size and degree of differentiation of cervical squamous cell carcinoma（P〉0.05）,it was related to the stage and lymph node metastasis of cervical squamous cell carcinoma（P〈0.05）.Spearman correlation analysis showed that the expression level of Gal-3 and PD-1 was positively correlated in cervical squamous cell carcinoma（r=0.496,P=0.000）.Conclusion：The expression level of Gal-3 and PD-1 is closely related to the occurrence and development of cervical squamous cell carcinoma,and there is a significant positive correlation between the two indicators.

关 键 词：宫颈鳞癌 半乳糖凝集素-3 程序性死亡受体-1 表达 临床意义 

分 类 号：R737.33[医药卫生—肿瘤]