乌司他丁辅助治疗急性重症胰腺炎的疗效及对occludin、CRPI、IL-6水平的影响  

Effects of Magnesium Isobutyrate Supplementation on CAM-1,CRPI,IL-2 Levels and Organ Function in Patients with Acute Severe Pancreatitis

作　　者：吴军 唐宁[2] 黄婷婷[3] 陈雅洁[3] 魏崇莉[4] WU Jun;TANG Ning;HUANG Ting-ting;CHEN Ya-jie;WEI Chong-li(The Department of intensive medicine,Southern Anhui rehabilitadon hospital,Wuhu,Anhui,241000,China;ICU,emergency department,Wangnan Medical College yijishan Hospital ofAnhui,Wuhu,Anhui,241000,China;Department of Neurology,Wangnan Medical College,Wuhu,Anhui,241000,China;Outpatient department,Lanzhou Military District Office,Lanzhou,Gansu,730000,China)

机构地区：[1]安徽省皖南康复医院重症医学科,安徽芜湖241000 [2]皖南医学院弋矶山医院急诊重症医学科,安徽芜湖241000 [3]皖南医学院弋矶山医院神经内科,安徽芜湖241000 [4]兰州军区机关门诊部,甘肃兰州730000

出　　处：《现代生物医学进展》2018年第18期3593-3596,共4页Progress in Modern Biomedicine

基　　金：安徽省科技计划基金项目(2011018)

摘　　要：目的:研究乌司他丁辅助治疗急性重症胰腺炎的疗效及对咬合蛋白(Occludin)、C反应蛋白(快速)(CRPI)、白细胞介素6(IL-6)水平的影响。方法:选择2014年12月至2016年11月在我院进行治疗的118例急性重症胰腺炎患者,随机将其均分为观察组(59例)和对照组(59例),对照组给予常规治疗,观察组患者则在对照组治疗方案的基础上增加乌司他丁辅助治疗,两组患者的治疗疗程均为两周,记录并比较两组患者治疗前后的血清occludin、CRPI、IL-6水平,治疗后腹胀、腹痛、恶性呕吐及腹膜刺激征等体征消失时间及临床疗效。结果:治疗后,观察组和对照组患者的总有效率分别是88.1%、69.5%,观察组总有效率显著高于对照组(P<0.05);观察组患者治疗后的血清occludin水平较对照组患者显著升高(P<0.05),血清IL-6及CRPI水平显著低于对照组,且腹胀、腹痛、恶性呕吐、腹膜刺激征等体征消失时间显著短于对照组(P<0.05)。结论:乌司他丁辅助治疗重症急性胰腺炎的临床疗效显著优于常规治疗,不仅能改善腹胀、腹痛、恶性呕吐及腹膜刺激征,而且可有效降低患者血清CRPI、IL-6水平和提高occludin水平。Objective：To study the efficacy of ulinastatin in the treatment of acute severe pancreatitis and its effect on the serum occludin,C-reactive protein（rapid,CRPI） and Interleukin 6（IL-6） levels.Methods：Eleven patients with acute severe pancreatitis from December 2014 to November 2016 were randomly divided into the observation group（n=59） and the control group（n=59）.The control group was given routine treatment,while the patients in observation group were treated with ulinastatin on the basis of control group.Both groups were treated for two weeks.The serum occludin,CRPI and IL-6 levels were recorded and compared between the two groups before and after treatment.The disappearance time of abdominal distension,abdominal pain,malignant vomiting and peritoneal irritation signs and other signs and clinical efficacy were also compared.Results：After treatment,the total effective rate was 88.1% in the observation group and 69.5% in the control group（P〈0.05）,the levels of serum occludin in the observation group were significantly higher than that in the control group（P〈0.05）,the serum IL-6 and CRPI levels were significantly lower than those in the control group,the disappearance time of abdominal distension,abdominal pain,malignant vomiting and peritoneal irritation were significantly shorter in the observation group than those in the control group（P〈0.05）.Conclusion：The clinical efficacy of ulinastatin in the treatment of severe acute pancreatitis is superior to conventional treatment,it can not only improved the bloating,abdominal pain,malignant vomiting and peritoneal irritation,but also effectively reduce the serum CRPI,IL-6 levels and increase the serum occludin level.

关 键 词：乌司他丁 急性重症胰腺炎 咬合蛋白 C反应蛋白(快速) 白细胞介素6 

分 类 号：R576[医药卫生—消化系统]