B7-H1和B7-H4在口腔鳞状细胞癌组织中的表达及临床意义  

Expression and Clinical Significance of B7-H1 and B7-H4 in Oral Squamous Cell Carcinoma Tissues

作　　者：王海涛 静广平[1] 田兵[1] 俞晴 钟克涛 胡腾龙[1] WANG Hai-tao;JING Guang-ping;TIAN Bing;YU Qing;ZHONG Ke-tao;HU Teng-long(Department of Oral Surgery Affiliated Stomatology Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学口腔医学院口腔外科二病房,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2018年第19期3623-3627,共5页Progress in Modern Biomedicine

基　　金：黑龙江省应用技术与开发计划项目(GA14C101-10)

摘　　要：目的:探讨口腔鳞状细胞癌(Oral Squamous Cell Carcinoma,OSCC)中B7-H1和B7-H4的表达及其临床意义,并为OSCC的临床诊断、治疗、判断预后及预防等提供依据。方法:采用免疫组织化学S-P法检测B7-H1及B7-H4在60例OSCC及20例非肿瘤患者正常口腔黏膜组织(NOM)中的表达情况,分析两者与OSCC临床病理特征的相关性。结果:B7-H1在OSCC组织中表达显著高于在NOM组织中表达(29例,48.3%v4例,20%,x^2=4.969,P<0.05);B7-H4在OSCC组织中表达亦显著高于在NOM组织中表达(31例,51.7%v5例,25%,x^2=4.310,P<0.05)。B7-H1与B7-H4在OSCC组织的表达都与TNM分期、淋巴结转移和肿瘤分化程度显著相关(P<0.05),而与年龄、性别及肿瘤直径大小等无关。OSCC组织中B7-H1和B7-H4的高表达呈显著性正相关性(x^2=5.613 P<0.05),60例组织中B7-H1和B7-H4共表达现象有11例(18.3%),NOM中未发现两者共表达现象。结论:B7-H1和B7-H4过表达与OSCC发生、发展及预后有关,可以作为预后指标。Objective： To explore the expression of B7-H1 and B7-H4 in Oral Squamous Cell Carcinoma（OSCC） and its clinical significance, and provide the basis for clinical diagnosis, treatment, prognosis and prevention of OSCC. Methods： Using immunohistochemical S-P method to detect B7-H1 and B7-H4 in 60 patients with OSCC and 20 cases of tumor expression innormal oral mucosa tissues（NOM）, and the correlation with clinical pathological characteristics of OSCC are analyzed. Results： The expression ofB7-H1 in OSCC was significantly higher than that in the NOM group（29 cases, 48.3% v4, 20%, x^2=4.969, P〈0.05）. The expression of B7-H4 in OSCC was also significantly higher than that in the NOM group（31 cases, 51.7% v5, 25%, x^2=4.310, P〈0.05）. The expression of B7-H1 and B7-H4 in OSCC was significantly correlated with TNM staging, lymph node metastasis and tumor differentiation（P〈0.05）, regardless of age, sex and tumor diameter. The high expression of B7-H1 and B7-H4 in OSCC tissues showed significant positive correlation（x^2=5.613 P〈0.05）. There were 11 cases（18.3%） in the total expression of B7-H1 and B7-H4 in the 60 cases, and no common expression was found in NOM. Conclusion： B7-H1 and B7-H4 overexpression are associated with the occurrence, development and prognosis of OSCC,which can be used as prognostic indicators.

关 键 词：口腔鳞状细胞癌 B7-H1 B7-H4 免疫组织化学 

分 类 号：R-33[医药卫生] R739.8