血清及胸腔积液中CA19-9、SCC-Ag及CYFRA21-1对肺癌诊断意义的对比研究  

Comparative Study of CA19-9, SCC-Ag and CYFRA21-1 in Serum and Pleural Effusion in the Diagnosis of Lung Cancer

作　　者：陈秀英[1] 陈怡舟 徐红 李佳芯 肖雄 CHEN Xiu-ying;CHEN Yi-zhou;XU Hong;LI Jia-xin;XIAO Xiong(Department of Respiratory,The First People＇s Hospital of Neijiang,Neijiang,Sichuan,641000,China;Department of Radiology,The First People＇s Hospital ofNeijiang,Neijiang,Sichuan,641000,China;Department ofPediatn＇cs,Xichang Matermity and Child Healthcare Hospital,Xichang,Sichuan,615050,China)

机构地区：[1]内江市第一人民医院呼吸科,四川内江641000 [2]内江市第一人民医院放射科,四川内江641000 [3]西昌市妇幼保健院儿科,四川西昌615050

出　　处：《现代生物医学进展》2018年第19期3733-3736,3794,共5页Progress in Modern Biomedicine

基　　金：四川省卫生厅科研基金资助项目(120478)

摘　　要：目的:探讨肺癌患者血清及胸腔积液中的糖蛋白抗原19-9(CA19-9)、鳞状细胞癌抗原(SCC-Ag)和细胞角蛋白19片段(CYFRA21-1)对肺癌的诊断意义。方法:选取2016年1月到2017年6月在我院接受治疗的肺癌患者67例作为肺癌组,另选取我院同期收治的肺良性病变患者55例纳入良性病变组。采用电化学发光法检测并对比两组患者血清及胸腔积液中的CA19-9、SCC-Ag和CYFRA21-1水平,比较所有研究对象血清及胸腔积液中CA19-9、SCC-Ag和CYFRA21-1的阳性率并分析其诊断价值。结果:肺癌组患者血清及胸腔积液中的CA19-9、SCC-Ag和CYFRA21-1水平显著高于良性病变组,有统计学差异(P<0.05)。CA19-9、SCC-Ag和CYFRA21-1在胸腔积液中的阳性率高于在血清中的阳性率,有统计学差异(P<0.05)。胸腔积液中CA19-9、SCC-Ag和CYFRA21-1单项检测对肺癌的灵敏度显著高于血清检测,血清及胸腔积液中CA19-9、SCC-Ag和CYFRA21-1三项联合检测的灵敏度、特异性、阳性预测值均高于单项检测,差异均有统计学意义(P<0.05)。结论:肺癌患者血清及胸腔积液中CA19-9、SCC-Ag和CYFRA21-1呈现高表达,三项指标联合检测可提高诊断肺癌的灵敏度、特异性和阳性预测值。Objective： To investigate the diagnostic significance of glycoprotein antigen 19-9（CA19-9）, squamous cell carcinoma antigen（SCC-Ag） and cytokeratin 19 fragment（CYFRA21-1） in serum and pleural effusion in patients with lung cancer. Methods： 67 cases of lung cancer patients treated in our hospital from January 2016 to June 2017 were selected as lung cancer group, and 55 cases of benign pulmonary lesions treated in our hospital during the same period were selected benign lesions group. The levels of CA19-9,SCC-Ag and CYFRA21-1 in serum and pleural effusion in two groups were detected by Electrochemiluminescence Method and compared. The positive rates of CA19-9, SCC-Ag and CYFRA21-1 in serum and pleural effusion of all patients were compared and the diagnostic value was analyzed. Results： The levels of serum and pleural effusion CA19-9, SCC-Ag and CYFRA21-1 in lung cancer group were significantly higher than that in benign lesions group, the differences were statistically significant（P〈0.05）. The positive rate of CA19-9, SCC-Ag and CYFRA21-1 in pleural effusion were significantly higher than that in serum, the differences were statistically significant（P〈0.05）. The sensitivity of pleural effusion CA19-9, SCC-Ag and CYFRA21-1 single detection of lung cancer were significantly higher than that in serum, and serum and pleural effusion CA19-9, SCC-Ag and CYFRA21-1 three joint detection sensitivity, specificity,positive predictive value were significantly higher than that of single detection, the differences were statistically significant（P〈0.05）.Conclusion： The expression of CA19-9, SCC-Ag and CYFRA21-1 in serum and pleural effusion of patients with lung cancer is highly expressed. The joint detection of three indicators can improve the sensitivity, specificity and positive predictive value of the diagnosis of lung cancer.

关 键 词：肺癌 糖蛋白抗原19-9 鳞状细胞癌抗原 细胞角蛋白19片段 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]