18^F－FDG PET/CT显像有助于不明原因腹腔积液女性患者的积液定性及病因诊断  

18^F-FDG PET/CT imaging contributes to the qualitative and etiological diagnosis for ascites of unknown origin in female patients

作　　者：李凤岐[1] 李现军[1] 赵志华[1] 宋振国[1] 王运 Li Fengqi;Li Xianjun;Zhao Zhihua;Song Zhenguo;Wang Yun(Department of Nuclear Medicine,Weifang People＇s Hospital,Weifang 261041,China;Department of Nuclear Medicine,Zhejiang Cancer Hospital,Hangzhou 310022,China)

机构地区：[1]潍坊市人民医院核医学科261041 [2]浙江省肿瘤医院核医学科,杭州310022

出　　处：《中华核医学与分子影像杂志》2018年第10期668-671,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：山东省医药卫生科技发展计划项目（2017WS894）;潍坊市科技发展计划项目（2016YX004）

摘　　要：目的分析不明原因腹腔积液女性患者的18F－脱氧葡萄糖（FDG） PET/CT显像特征，并探讨其诊断价值。方法回顾性分析2011年4月至2016年12月间因不明原因腹腔积液行18F－FDG PET/CT或经PET/CT发现腹腔积液的117例女性患者，平均年龄58岁；分析患者腹腔积液的病因分布、PET/CT显像积液代谢水平、PET/CT对恶性腹腔积液患者肿瘤原发灶及转移灶的定位诊断效能。采用两样本t检验分析数据。结果女性腹腔积液患者病因以卵巢癌多见，占35.0%（41/117）；恶性积液者积液平均标准摄取值（SUVmean）高于良性者（1.41±0.40与0.94±0.47；t＝3.92, P〈0.05）；18F－FDG PET/CT对恶性积液肿瘤原发或转移灶定位诊断的检出率为89.4%（93/104），对卵巢癌来源的恶性病灶检出率为75.6%（31/41）；在卵巢癌所致积液患者中，PET/CT明确定位了24.4%（10/41）的原发灶和51.2%（21/41）的转移灶。结论卵巢癌是女性腹腔积液患者的最常见原因；18F－FDG PET/CT对女性不明原因腹腔积液的定性及病因鉴别诊断具有较高价值。ObjectiveTo evaluate the diagnostic role of 18F-fluorodeoxyglucose （FDG） PET/CT in female patients with ascites of unknown origin by analyzing the characteristics of PET/CT images.MethodsFrom April 2011 to December 2016, 117 female （average age： 58 years） with ascites of unknown origin who underwent 18F-FDG PET/CT or whose ascites were found by PET/CT were retrospectively analyzed. The causes of ascites, level of ascites metabolism in PET/CT, diagnostic efficacy of PET/CT for localizing primary tumor and metastasis were analyzed. Two-sample t test was used to analyze the data.ResultsThe most common cause of female ascites was ovarian cancer, accounting for 35.0%（41/117）. The mean standardized uptake value （SUVmean） of malignant ascites was higher than that of benign ascites （1.41±0.40 vs 0.94±0.47; t=3.92, P〈0.05）. The total detection rate of 18F-FDG PET/CT for primary or metastatic tumor in malignant ascites was 89.4%（93/104）, and 75.6%（31/41） for malignant ascites originating from ovarian cancer. For patients with ovarian cancer, 18F-FDG PET/CT clearly localized the primary tumors in 24.4%（10/41） patients and metastasis in 51.2%（21/41） patients.ConclusionsOvarian cancer is the most common cause of female ascites. 18F-FDG PET/CT has a high diagnostic value for qualitative and etiological diagnosis for ascites of unknown origin in females.

关 键 词：腹水 肿瘤 诊断 鉴别 正电子发射断层显像术 体层摄影术 X线计算机 脱氧葡萄糖 

分 类 号：R730.44[医药卫生—肿瘤]