2006和2016年长春市1～59岁人群乙型肝炎血清流行病学调查分析  

Seroprevalence of hepatitis B in populations at ages of 1～59 years in Changchun City,Jilin Province,China in 2006 and 2016

作　　者：陶育晖[1] 闫莉[1] 王崇[1] 徐红芹 张君鹏 于建星 TAO Yu-hui;YAN Li;WANG Chong;XU Hong-qin;ZHANG Jun-peng(YU Jian-xing Changchun Municipal Center for Disease Control and Prevention,Changchun 130033,Jilin Province,China)

机构地区：[1]长春市疾病预防控制中心,吉林长春130033

出　　处：《中国生物制品学杂志》2018年第10期1114-1117,共4页Chinese Journal of Biologicals

摘　　要：目的分析长春市2006和2016年1～59岁人群乙型肝炎(简称乙肝)血清流行病学调查结果。方法按照多阶段整群随机抽样的方法,抽取长春市的德惠市和南关区1～59岁人群进行乙肝表面抗原(hepatitis B surface antigen,HBsAg)携带率、乙肝表面抗体(hepatitis B surface antibody,HBsAb)阳性率和乙肝疫苗(hepatitis B vaccine,HepB)接种率调查分析。结果 2006年932名和2016年1 097名调查对象中,HBsAg携带率分别为3.22%和1.64%,HBsAb阳性率分别为51.07%和52.51%,HepB接种率分别为58.15%和67.73%。不同年龄段间HBsAg携带率、HBsAb阳性率及HepB接种率的差异均有统计学意义(P<0.05),性别间HBsAg携带率、HBsAb阳性率及HepB接种率的差异均无统计学意义(P>0.05);城乡间HBsAb阳性率及HepB接种率的差异均有统计学意义(P<0.05),2006年城乡间HBs Ag携带率差异有统计学意义(P<0.05),2016年差异无统计学意义(P>0.05)。结论10年间HepB接种率有所提高,HBsAg携带率下降,HBsAb阳性率变化较小。Objective To compare the seroprevalence of hepatitis B in populations at ages of 1 - 59 years in Changchun City, Jilin Province, China in 2006 and 2016. Methods A multi-stage cluster random sampling method was used for analysis of hepatitis B surface antigen （HBsAg） carriage rate, hepatitis B surface antibody （HBsAb） positive rate and coverage of hepatitis B vaccine （HepB） in populations at ages of 1 - 59 years in Dehui County and Nanguan District of Changchun City. Results The HBsAg carriage rates in 932 subjects in 2006 and 1 097 subjects in 2016 were 3. 22% and 1.64%, while the HBsAb positive rates were 51.07% and 52. 51%, and the HepB coverage rates were 58. 15% and 67. 73%, respectively, which showed significant difference in the subjects at various age stages （P 〈 O. 05）, while showed no significant difference in male and female subjects （P 〉 O. 05 ）. Both HBsAb positive rate and HepB coverage rate showed significant difference in urban and in rural areas （P 〈 0. 05）. However, the HBsAg carrier rate showed significant difference in urban and rural areas in 2006 （P 〈 0. 05）, while showed no significant difference in 2016 （P 〉 O. 05）. Conclusion During the past ten years, the HepB coverage rate in Changehun increased, while the HBsAg carriage rate decreased, and the HBsAb positive rate showed no significant change.

关 键 词：乙型肝炎 乙型肝炎疫苗 携带率 接种率 

分 类 号：R373.21[医药卫生—病原生物学] R181.2[医药卫生—基础医学]