吉西他滨膀胱灌注化疗预防非肌层浸润性膀胱癌术后复发的效果及安全性  

Effect of gemcitabine intravesical instillation chemotherapy in the prevention of postoperative recurrence of non-muscle invasive bladder cancer and its safety

作　　者：贺艳锋 马永图 高卫军 HE Yan-feng;MA Yong-tu;GAO Wei-jun(No.215 Hospital of Shaanxi Provincal Nuclear Industry,Xianyang 712000,China)

机构地区：[1]陕西省核工业二一五医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2018年第32期68-69,79,共3页Clinical Research and Practice

摘　　要：目的评价吉西他滨膀胱内灌注预防膀胱癌术后复发的疗效。方法选取2012年1月至2015年12月我院泌尿外科经尿道膀胱肿瘤电切手术治疗的40例膀胱肿瘤患者,随机分为试验组(22例)和对照组(18例)。试验组患者术后即刻给予吉西他滨膀胱灌注化疗,对照组术后即刻给予吡柔比星膀胱灌注化疗。比较两组患者的治疗效果。结果试验组2年无复发生存率及复发率优于对照组(P<0.05)。试验组的膀胱刺激症状总发生率低于对照组(P<0.05)。两组患者均未发生尿道狭窄和全身不良反应。结论非肌层浸润性膀胱癌患者术后给予吉西他滨膀胱灌注化疗可有效降低膀胱癌术后复发率,安全性较高,值得临床推广。Objective To evaluate the effect of gemcitabine intravesical instillation chemotherapy in the prevention ofpostoperative recurrence of non -muscle invasive bladder cancer. Methods Forty patients with bladder cancer whounderwent transurethral resection of urethral bladder cancer from January 2012 to December 2015 were randomly dividedinto experimental group （22 cases） and control group （18 cases）. Patients in the experimental group were given intravesicalperfusion chemotherapy with gemcitabine immediately after surgery. Patients in the control group were given intravesicalperfusion chemotherapy with pirarubicin immediately after surgery. The treatment effects of the two groups were compared.Results The 2-year recurrence-free survival rate and recurrence rate of the experimental group were superior to those ofthe control group （P〈0.05）. The total incidence of bladder irritation in the experimental group was lower than that in thecontrol group （P〈0.05）. No urethral stricture or systemic adverse reactions occurred in patients of the two group.Conclusion Gemcitabine intravesical instillation chemotherapy in the treatment of non-muscle invasive bladder cancer candecrease the recurrence rate, with high safety, which is worthy of clinical promotion.

关 键 词：吉西他滨 膀胱灌注化疗 膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]