神经胶质细胞在出血性脑损伤中的作用及可能的干预靶点  

Role of glial cell in cerebral hemorrhage injury and potential targets for intervention

作　　者：李敏淑[1] 任洪磊 朱晓冬[1] 常宝成[2] Li Minshu, Ren Honglei, Zhu Xiaodong, Chang Baocheng.(Department of Neurology, Tianjin Medical University General Hospital, Tianfin Neurological Institute, Tianjin 300052, China)

机构地区：[1]天津医科大学总医院神经内科天津市神经病学研究所,300052 [2]天津医科大学代谢病医院内分泌科

出　　处：《中国医师进修杂志》2018年第11期1042-1046,共5页Chinese Journal of Postgraduates of Medicine

基　　金：国家自然科学基金 （81701176）;天津市教育委员会项目 （2016YD04） ;天津市应用基础与前沿技术研究计划 （15JCYBJC50000）

摘　　要：脑出血是严重危害人类生命安全的难治性疾病之一。免疫和炎性反应参与脑出血的全过程，它能破坏血脑屏障，加速脑水肿，同时又能启动和放大氧化应激反应，加重脑出血后神经功能损伤。脑出血后产生多种危险信号分子，这些分子迅速激活血肿周围区域的小胶质细胞和星形胶质细胞，使其产生炎性因子及氧化介质，调控脑部的炎性反应。现探讨神经胶质细胞与免疫和炎性反应的相关性，有望发现针对神经胶质细胞的脑出血干预新靶点，开发新的脑出血治疗药物和方案。Cerebral hemorrhage is one of the refractory diseases which seriously endangers the safety of human life. Immune and inflammatory reaction participate in the whole process of cerebral hemorrhage, which can destroy the blood-brain barrier, accelerate brain edema, at the same time start and amplify the oxidative stress reaction, and aggravate the nerve function damage. After cerebral hemorrhage, many kinds of signal molecules are produced, which can activate the microglia and astrocytes around the hematoma, produce inflammatory factors and oxidizing mediators, and regulate the inflammatory response of the brain. Exploring the relationship between glial cell and immune, inflammatory responses is helpful to understand the mechanism of intracerebral hemorrhage intervention, find out a new target for the intervention of glial cells and develop new drugs and schemes for the treatment of intracerebral hemorrhage.

关 键 词：脑出血 神经胶质 综述 

分 类 号：R743.34[医药卫生—神经病学与精神病学]