家族性急性髓细胞白血病的诊断  

Diagnosis of familial acute myeloid leukemia

作　　者：尹春琼 白志瑶 包艳 Yin Chunqiong;Bai Zhiyao;Bao Yan(Department of Laboratory Qujing Second People＇s Hospital,Qujing 655000,Yunnan,China)

机构地区：[1]曲靖市第二人民医院检验科,云南曲靖655000

出　　处：《实用检验医师杂志》2018年第3期184-186,共3页Chinese Journal of Clinical Pathologist

摘　　要：曲靖市第二人民医院于2016年9月26日收治1例急性髓细胞白血病(AML)-M2b男性患者,该患者经血液细胞分析、血涂片、骨髓涂片、白血病融合基因检查以及流式细胞免疫分型确诊。患者母亲于2017年4月23日因消化道出血收入消化内科,4月26日被确诊为AML-M2a。分析家族性白血病(FL)的临床特征和发病规律。我国FL以父(母)子(女)关系及亲兄弟姐妹关系最为常见,且以AML及慢性粒细胞白血病(CML)为主。早期发现FL对提高治疗效果至关重要,故对FL的高危人群随访应引起临床医生重视。A male patient initially diagnosed as acute myeloid leukemia was admitted into Qujing Second People＇s Hospital on September 26, 2016. After admission, he had undergone many examinations, such as blood cell analysis, blood smear, bone marrow smear, leukemia fusion gene test and flow cell immunophenotyping detection, and finally he was definitely diagnosed as acute myeloid leukemia（AML）-M2 b. On April 23, 2017, his mother was admitted into the Department of Gastroenterology in this hospital because of digestive tract bleeding, and on April 26, her definite diagnosis was also AML-M2 a. The clinical characteristics and occurrence regularity of familial leukemia（FL） were analyzed. In China, the hereditary transmission of this disease is mostly often seen in father（mother） and son（daughter） relationship, so among members of full sibling relationship more than one of FL patient can be found, and the main types of leukemia are AML and chronic granulocytic leukemia. The early detection of FL is of great importance, as early proper treatment can get better therapeutic effect, therefore, clinicians should pay attention to the follow-up of the people who have high risk of familial leukemia.

关 键 词：家族性白血病 急性髓细胞白血病 临床特征 

分 类 号：R733.71[医药卫生—肿瘤]