认识非活化溴代芳烃化合物甲氧基化生产技术演进过程,全面培养学生专业思维能力  

Realization of the Evolution of Manufacturing Techniques in Methoxylation of Unactivated Bromoarenes, Comprehensive Cultivation of Students' Professional Thinking Ability

作　　者：冀亚飞[1] 刘宏伟[1] 赵建宏[1] 马红梅[1] 罗晓燕[1] 韩伟[1] 虞心红[1] 任国宾[1] 宋恭华[1] Ji Yafei;Liu Hongwei;Zhao Jianhong;Ma Hongmei;Luo Xiaoyan;Han Wei;Yu Xinhong;Ren Guobin;Song Gonghua

机构地区：[1]华东理工大学药学院,上海200237

出　　处：《化工高等教育》2018年第5期85-90,共6页Higher Education in Chemical Engineering

基　　金：2017年度上海市教委本科精品课程建设项目(YC0126114);2017年中央教改专项专业核心课程建设项目(ZC1726103);国家自然科学基金(21476074和21676088)

摘　　要：本文在介绍活化与非活化卤代芳烃化合物甲氧基化反应差异和过渡金属催化非活化卤代芳烃化合物甲氧基化反应的基础上,阐明了可工业化应用的铜催化非活化溴代芳烃化合物甲氧基化工艺的发展进程;通过介绍四代生产技术的实际应用,揭示了甲氧基化工艺研发的渐进过程,有助于学生完整理解工艺发展脉络。应用反应机理理解工艺原理能促使学生形成科学思维方式。On the basis of understanding of the difference between methoxylation of activated and unactivated haloarenes, as well as transition-metal catalyzed methoxylation of unactivated haloarenes, this paper expounded a development process for industrially applicable copper-catalyzed methoxylation techniques of unactivated bromoarenes. Through their practical application of four generations of manufacturing techniques, an evolutionary advance has been historically uncovered for research and development of the methoxylation processes, which is conducive for students to complete understanding of the development pulses. Furthermore, the application of well-defined reaction mechanism to explanation of technical principle would facilitate students to better establish a scientific thinking pattern.

关 键 词：制药工艺学 非活化溴代芳烃化合物 甲氧基化 生产工艺 绿色化学 

分 类 号：TQ460-4[化学工程—制药化工] G642[文化科学—高等教育学]