cis-4-甲氧基环己基-1-氨基甲酸的合成和优化  

Synthesis and Optimization of cis-1-Amino-4-methoxycyclohexanecarboxylic Methyl Acid

作　　者：薛健[1] 于春红 杜辉[1] 秦欢 XUE Jian;YU Chun-hong;DU Hui;QIN Huan(Nantong Jiangshan Agrochemical ＆ Chemicals Co.,Ltd.,Nantong 226017,Jiangsu,China)

机构地区：[1]南通江山农药化工股份有限公司,江苏南通226017

出　　处：《农药》2018年第10期710-711,共2页Agrochemicals

摘　　要：[目的]研究cis-4-甲氧基环己基-1-氨基甲酸的合成新方法。[方法]以cis-8-甲氧基-1,3-二氮杂螺[4,5]癸-2,4-二酮(简称LC-酰胺)为起始原料,在氢氧化钡碱性条件下水解得到目标产物。[结果] cis-4-甲氧基环己基-1-氨基甲酸的顺式含量达98%以上,收率达96%。[结论]该合成新方法具有含量高、收率高、操作简便,能有效避免副产氯化钠盐的生成。[Aims] A new synthetic method for cis-4-methoxycyclohexane-1-amino-carboxylic acid was studied.[Methods] The target product was obtained by hydrolysis of starting material cis-8-methoxy 1,3-diaza-spiro[4,5]decane2,4-dione under alkaline conditions of barium hydroxide. [Results] The content of cis-4-methoxycyclohexane-1-amino-carboxylic acid reach above 98%, and the yield reach 96%. [Conclusions] The new process has the advantages of simple operation, high content, high yield, and can effectively avoid the formation of by-product sodium chloride.

关 键 词：cis-4-甲氧基环己基-1-氨基甲酸 cis-8-甲氧基-1 3-二氮杂螺[4 5]癸-2 4-二酮(LC-酰胺) 优化 

分 类 号：TQ460.3[化学工程—制药化工]