柯拉斯那沉香中的1个新倍半萜  

A new sesquiterpenoid of agarwood from Aquilaria crassna

作　　者：王佩[1] 康科星 孔凡栋[1] 周丽曼[1] 朱国鹏 戴好富[1] 梅文莉 WANG Pei;KANG Ke-xing;KONG Fan-dong;ZHOU Li-man;ZHU Guo-peng;DAI Hao-ful;MEI Wen-li(Key Laboratory of Biology and Genetic Resources of Tropical Crops,Ministry of Agriculture,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China;Institute of Tropical Agriculture and Forestry,Hainan University,Haikou 570228,China)

机构地区：[1]中国热带农业科学院热带生物技术研究所/农业部热带作物生物学与遗传资源利用重点实验室,海南海口571101 [2]海南大学热带农林学院,海南海口570228

出　　处：《中草药》2018年第19期4480-4483,共4页Chinese Traditional and Herbal Drugs

基　　金：现代农业产业技术体系建设专项资金资助(CARS-21);中国热带农业科学院院级创新团队南药产业技术创新团队(17CXTD-15);中国热带农业科学院热带生物技术研究所基本科研业务费(1630052016008);海南自然科学基金创新研究团队项目(2017CXTD020)

摘　　要：目的研究柯拉斯那沉香Aquilaria crassna的化学成分。方法采用多种柱色谱对柯拉斯那沉香的化学成分进行分离纯化;通过波谱数据结合理化性质进行化合物结构鉴定;采用p NPG法对所得化合物的α-葡萄糖苷酶抑制活性进行测试。结果从柯拉斯那沉香的醋酸乙酯提取物中分离得到1个新的倍半萜类化合物和2个已知色原酮类化合物,分别鉴定为柯拉斯那酸甲酯(1)、8-氯-6-羟基-2-(2-苯乙基)色酮(2)、8-氯-6-羟基-2[2-(4-甲氧基)苯乙基]色酮(3)。结论化合物1为新化合物,命名为柯拉斯那酸甲酯。活性测试结果表明化合物1具有α-糖苷酶抑制活性,半数抑制浓度(IC50)值为121.8μg/mL。Objective To study the chemical constituents of agarwood from Aquilaria crassna. Methods The compounds were isolated and purified by various column chromatographic techniques. Their structures were identified on the basis of spectral data and physicochemical properties. And the compounds were tested for α-glucosidase inhibitory activity by p NPG method. Results One new sesquiterpenoid along with two known chromones, which were determined as methyl crassicid（1）, 8-chloro-6-hydroxy-2-（2-phenethyl） chromen-4-one（2）, 8-chloro-6-hydroxy-2-[2-（4-methoxyphenyl） ethyl] chromen-4-one（3）, were obtained from the ethyl acetate extract obtained from 95% ethanol extract of agarwood from A. crassna. Conclusion Compound 1 is a new sesquiterpenoid named sesquiterpenoid, which exhibited α-glucosidase inhibitory activity with IC50 value of 121.8 μg/mL.

关 键 词：沉香 柯拉斯那沉香 倍半萜 色酮 柯拉斯那酸甲酯 Α-葡萄糖苷酶 

分 类 号：R284.1[医药卫生—中药学]